Is there a role for melatonin in the ICU?

In the last decade, there have been significant developments in the understanding of the hormone melatonin in terms of its physiology, regulatory role and potential utility in various domains of clinical medicine. Melatonin's purported properties include, among others, regulation of mitochondri...

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Bibliographic Details
Published in:The Southern African journal of critical care 2021-08, Vol.37 (2), p.77
Main Authors: Richards, G. A, Bentley, A, Gopalan, P. D, Brannigan, L, Paruk, F
Format: Article
Language:English
Subjects:
Delirium
Dexmedetomidine
Melatonin
Physiological aspects
Ramelteon
Review
Online Access:Get full text
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Summary:In the last decade, there have been significant developments in the understanding of the hormone melatonin in terms of its physiology, regulatory role and potential utility in various domains of clinical medicine. Melatonin's purported properties include, among others, regulation of mitochondrial function, anti-inflammatory, anti-oxidative and neuro-protective effects, sleep promotion and immune enhancement. As such, its role has been explored specifically in the critical care setting in terms of many of these properties. This review addresses the physiological basis for considering melatonin in the critical care setting as well as the current evidence pertaining to its potential utility. Keywords. melatonin; sleep; delirium; sepsis; intensive care unit.
ISSN:1562-8264
2078-676X
DOI:10.7196/SAJCC.2021.v37i2.490