Efficient synthesis of 1-iodoalkynes via Al2O3 mediated reaction of terminal alkynes and N-iodosuccinimide

Iodination of terminal alkynes using N-iodosuccinimide (NIS) in the presence of γ-Al2O3 was developed to afford 1-iodoalkynes with good to excellent yields (up to 99%). This described approach featured excellent chemoselectivity, good functional group tolerance, and utilization of an inexpensive cat...

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Bibliographic Details
Published in:RSC advances 2020-01, Vol.10 (7), p.3946-3950
Main Authors: Yao, Ming, Zhang, Jingjing, Sen, Yang, Xiong, Hangxing, Li, Li, Liu, E, Shi, Hong
Format: Article
Language:English
Subjects:
Alkynes
Aluminum oxide
Chemistry
Functional groups
Iodination
Transitional aluminas
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Description
Summary:Iodination of terminal alkynes using N-iodosuccinimide (NIS) in the presence of γ-Al2O3 was developed to afford 1-iodoalkynes with good to excellent yields (up to 99%). This described approach featured excellent chemoselectivity, good functional group tolerance, and utilization of an inexpensive catalyst.
ISSN:2046-2069
2046-2069
DOI:10.1039/d0ra00251h