New triterpenoid saponin glycosides from the fruit fibers of Trichosanthes cucumerina L

Five new triterpenoid saponin glycosides, trichocucumerisides A-E (1-5), together with eleven known compounds (6-16) were isolated from fruit fibers. The structures of the new compounds were elucidated by detailed analysis of NMR and mass spectroscopic data as well as chemical reactions. The anti-in...

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Published in:RSC advances 2020-03, Vol.10 (18), p.10461-10470
Main Authors: Suebsakwong, Parichat, Chulrik, Wanatsanan, Chunglok, Warangkana, Li, Jian-Xin, Yao, Zhu-Jun, Suksamrarn, Apichart
Format: Article
Language:English
Subjects:
Chemical reactions
Chemistry
Glycosides
Nitric oxide
NMR
Nuclear magnetic resonance
Saponins
Selectivity
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cited_by cdi_FETCH-LOGICAL-c370t-5d1a134491afa83829a7afd886026900a7e64d793ed900b89ccf9351d396021b3
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container_title RSC advances
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Chulrik, Wanatsanan
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description Five new triterpenoid saponin glycosides, trichocucumerisides A-E (1-5), together with eleven known compounds (6-16) were isolated from fruit fibers. The structures of the new compounds were elucidated by detailed analysis of NMR and mass spectroscopic data as well as chemical reactions. The anti-inflammatory study against nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells shows that compounds 7 and 9 exhibited stronger NO inhibitory activity, with IC values of 3.0 and 2.7 μM, respectively, with comparison to positive references Celecoxib and aminoguanidine (IC values 75.7 and 75.0 μM, respectively). Compounds 7 and 9 also possessed a greater selectivity index (SI) of approximately 3-4-fold activity than that of the positive references.
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subjects Chemical reactions
Chemistry
Glycosides
Nitric oxide
NMR
Nuclear magnetic resonance
Saponins
Selectivity
title New triterpenoid saponin glycosides from the fruit fibers of Trichosanthes cucumerina L
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