Maternal effect factors that contribute to oocytes developmental competence: an update

Oocyte developmental competence is defined as the capacity of the female gamete to be fertilized and sustain development to the blastocyst stage. Epigenetic reprogramming, a correct cell division pattern, and an efficient DNA damage response are all critical events that, before embryonic genome acti...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2022-04, Vol.39 (4), p.861-871
Main Authors: Innocenti, Federica, Fiorentino, Giulia, Cimadomo, Danilo, Soscia, Daria, Garagna, Silvia, Rienzi, Laura, Ubaldi, Filippo Maria, Zuccotti, Maurizio
Format: Article
Language:English
Subjects:
Blastocyst
Cell division
Developmental stages
DNA damage
Embryonic Development - genetics
Embryos
Epigenetics
Female
Fertilization
Folliculogenesis
Genomes
Gynecology
Human Genetics
Humans
Infertility
Maternal Inheritance
Medicine
Medicine & Public Health
Meiosis
Meiosis - genetics
Oocytes
Oogenesis - genetics
Ovulation
Reproductive Medicine
Review
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Summary:Oocyte developmental competence is defined as the capacity of the female gamete to be fertilized and sustain development to the blastocyst stage. Epigenetic reprogramming, a correct cell division pattern, and an efficient DNA damage response are all critical events that, before embryonic genome activation, are governed by maternally inherited factors such as maternal-effect gene (MEG) products. Although these molecules are stored inside the oocyte until ovulation and exert their main role during fertilization and preimplantation development, some of them are already functioning during folliculogenesis and oocyte meiosis resumption. This mini review summarizes the crucial roles played by MEGs during oocyte maturation, fertilization, and preimplantation development with a direct/indirect effect on the acquisition or maintenance of oocyte competence. Our aim is to inspire future research on a topic with potential clinical perspectives for the prediction and treatment of female infertility.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-022-02434-y