Co-delivery of chlorantraniliprole and avermectin with a polylactide microcapsule formulation

• Published in: RSC advances 2020-07, Vol.1 (43), p.25418-25425
• Main Authors: Suraphan, Nuntanit, Fan, Linfeng, Liu, Baoxia, Wu, Decheng
• Format: Article
• Language: English
• Subjects: Chemistry; Drug delivery systems; Entrapment; Pesticides; Synergistic effect; Thermal stability; Water pollution
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/d0ra03825c

Improving drug utilization of water-based pesticide formulations is facile and feasible to efficiently avoid serious pesticide residues and reduce the resulting environmental pollution. A co-delivery system of two- or multi-pesticides within one formulation could enhance drug efficiency and decrease usage amounts of pesticides due to the synergistic effect of the loaded multiple pesticides. Herein, we reported a porous polylactide (PLA) microcapsule formulation for co-delivery of avermectin (Av) and chlorantraniliprole (CAP). A double emulsion method combined with premix membrane emulsion (PME) was adopted to produce the Av/CAP-loaded porous microcapsules (Av/CAP P-MCs) with prolonged drug release, high loading content and entrapment efficiency, as well as good light and thermal stability. Compared with single Av- or CAP-loaded microcapsule formulations, the Av/CAP P-MCs exhibited higher biotoxicity against Plutella xylostella . These results reveal that the Av/CAP co-delivery system may be a promising candidate to be further explored as a facile, effective and environmentally-friendly pesticide formulation. We constructed a porous PLA-microcapsule-based co-delivery system of chlorantraniliprole and avermectin using a double emulsion method combined with premix membrane emulsion.