Phytomedicines explored under in vitro and in silico studies against coronavirus: An opportunity to develop traditional medicines

•Repurposed drugs employed in the management of COVID-19 exhibit adverse effects.•Exploration of alternative treatment options i.e., traditional medicine, medicinal plants, and their phytochemicals with low toxicity profile.•Potent phytochemicals, their source plants, and traditional medicines, agai...

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Published in:South African journal of botany 2022-12, Vol.151, p.451-483
Main Authors: Gandhi, Yashika, Mishra, Sujeet K., Rawat, Hemant, Grewal, Jyotika, Kumar, Ravi, Shakya, Santosh K., Jain, Vipin Kumar, Babu, G., Singh, Arjun, Singh, Ravindra, Acharya, Rabinarayan, Kumar, Vijay
Format: Article
Language:English
Subjects:
Ayurveda
Coronavirus
COVID-19
Phytochemicals
Review
Traditional medicines
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Summary:•Repurposed drugs employed in the management of COVID-19 exhibit adverse effects.•Exploration of alternative treatment options i.e., traditional medicine, medicinal plants, and their phytochemicals with low toxicity profile.•Potent phytochemicals, their source plants, and traditional medicines, against coronavirus, have been reported.•The study will be a roadmap for further studies to develop traditional medicine against COVID-19 . The widespread COVID-19 pandemic, caused by novel coronavirus SARS-CoV-2, has emanated as one of the most life-threatening transmissible diseases. Currently, the repurposed drugs such as remdesivir, azithromycine, chloroquine, and hydroxychloroquine are being employed in the management of COVID-19 but their adverse effects are a matter of concern. In this regard, alternative treatment options i.e., traditional medicine, medicinal plants, and their phytochemicals, which exhibit significant therapeutic efficacy and show a low toxicity profile, are being explored. The current review aims at unraveling the promising medicinal plants, phytochemicals, and traditional medicines against SARS-CoV-2 to discover phytomedicines for the management of COVID-19 on the basis of their potent antiviral activities against coronaviruses, as demonstrated in various biochemical and computational chemical biology studies. The review consists of integrative and updated information on the potential traditional medicines against COVID-19 and will facilitate researchers to develop traditional medicines for the management of COVID-19.
ISSN:0254-6299
1727-9321
0254-6299
DOI:10.1016/j.sajb.2022.04.053