Down-regulation of MRPS23 inhibits LPS-induced proliferation and invasion via regulation of the NF-κB signaling pathway in osteosarcoma cells

Mitochondrial ribosomal protein S23 (MRPS23), encoded by a nuclear gene, is a participant in the translation of mitochondrial proteins. Recently, MRPS23 has been reported to be overexpressed in many types of cancers and have a close association with cancer progression. However, the specific roles of...

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Bibliographic Details
Published in:RSC advances 2019-04, Vol.9 (19), p.10561-10568
Main Authors: Liu, Ai-Guo, Xu, Ke-Lin, Wang, Wei-Lin, Zhou, Bing-Kang, Guo, Qing-Gong
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Bone cancer
Cell growth
Chemistry
Kinases
Proteins
Signaling
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Summary:Mitochondrial ribosomal protein S23 (MRPS23), encoded by a nuclear gene, is a participant in the translation of mitochondrial proteins. Recently, MRPS23 has been reported to be overexpressed in many types of cancers and have a close association with cancer progression. However, the specific roles of MRPS23 in osteosarcoma (OS) remain unknown. In this study, we investigated the expression pattern and biological functions of MRPS23 in OS cells. Our results demonstrated that MRPS23 was up-regulated in OS tissues and cell lines. Down-regulation of MRPS23 significantly inhibited OS cell proliferation and invasion induced by lipopolysaccharide (LPS) . Furthermore, the experiments showed that MRPS23 down-regulation markedly suppressed OS cell growth and metastasis induced by LPS. Mechanistically, down-regulation of MRPS23 inhibited the activity of NF-κB signaling pathway in OS cells. In conclusion, these findings indicated that MRPS23 may be a potential therapeutic target for OS treatment.
ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra08973f