Development of self-stratified antibacterial polymers via click chemistry

An azide-modified long perfluorinated tail quaternary ammonium methacrylate compound (M2) was designed and synthesized. The fluorine containing polyurethane (PU-F) with strong antibacterial properties was prepared click reaction of M2 and a clickable polymer (PU-Al), which exhibited surface segregat...

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Bibliographic Details
Published in:RSC advances 2019-01, Vol.9 (23), p.13159-13167
Main Authors: Peng, Kaimei, Hu, Jianqing, Dai, Xuexin, Yang, Zaibo, Wang, Runping, Tu, Weiping
Format: Article
Language:English
Subjects:
Antibacterial materials
Chemical reactions
Chemical synthesis
Chemistry
Conjugation
E coli
Fluorine
Leaching
Organic chemistry
Polyurethane resins
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Summary:An azide-modified long perfluorinated tail quaternary ammonium methacrylate compound (M2) was designed and synthesized. The fluorine containing polyurethane (PU-F) with strong antibacterial properties was prepared click reaction of M2 and a clickable polymer (PU-Al), which exhibited surface segregation. The PU-F film showed a total kill against both Gram-positive ( ) and Gram-negative ( ) at an M2 content around 1 wt%. A disk diffusion test confirmed that the ligation efficiency of the antibacterial agents and polymer chains click chemistry was excellent, and covalent conjugation of the QACs to the polymers prevented leaching.
ISSN:2046-2069
2046-2069
DOI:10.1039/c9ra01572h