Pyridylbenzimidazole based Re(i)(CO) 3 complexes: antimicrobial activity, spectroscopic and density functional theory calculations

• Published in: RSC advances 2019-05, Vol.9 (26), p.15108-15114
• Main Author: Mansour, Ahmed M
• Format: Article
• Language: English
• Subjects: Chemistry
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/c9ra01566c

-[ReBr(CO) (L )] L = 1-ethyl-2-(pyridin-2-yl)benzimidazole (1) and L = 1-[(pyridin-2-yl) benzimidazole]-propyl-sulfonic acid (2), -[Re Br (CO) L ] (3) L = 1,1'-(hexane-1,6-diyl)bis[2-(pyridin-2-yl)1 -benzimidazole] and -[ReBr(CO) (L -κ N N )] (L = 2,6-bis(benzimidazol-2'-yl)pyridine (4) and L = 2,6-bis(1-ethyl-benzimidazol-2'-yl)pyridine (5) were synthesized and fully characterized using different spectrocopic and analytical tools. The spectrocopic data showed coordination of L to -ReBr(CO) the benzimidazole and pyridine N-atoms. For 4 and 5, the absence of a two-fold axis of symmetry for L in the H NMR spectra reflect the κ N ,N mode of coordination. The electronic properties of 1-5 were investigated by time-dependent density functional theory calculations in the singlet and triplet states. The ligands and their Re(i) complexes were assessed for their potential antimicrobial activity. Compound 5 was screened against non-malignant cell line (noncancerous human embryonic kidney cell line (HEK293)) as well as evaluated for its blood compatibility.