Effects of Pramipexole Combined with Nerve Growth Factor on Cognitive Impairment and Urinary AD7c-NTP Expression in Patients with Parkinson’s Disease

Objective. To explore the effects of pramipexole combined with nerve growth factor (NGF) on cognitive impairment and urinary Alzheimer-associated neural thread protein (AD7c-NTP) expression in patients with Parkinson’s disease (PD). Methods. Fifty patients with PD treated in our hospital from Februa...

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Bibliographic Details
Published in:Computational and mathematical methods in medicine 2022-04, Vol.2022, p.3398732-8
Main Authors: Wang, Zhengxin, Cheng, Saiyu
Format: Article
Language:English
Subjects:
Brain-Derived Neurotrophic Factor
Cognitive Dysfunction - drug therapy
Cognitive Dysfunction - etiology
Humans
Interleukin-6
Nerve Growth Factor
Nerve Tissue Proteins
Parkinson Disease - drug therapy
Pramipexole
Serotonin
Tumor Necrosis Factor-alpha
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Summary:Objective. To explore the effects of pramipexole combined with nerve growth factor (NGF) on cognitive impairment and urinary Alzheimer-associated neural thread protein (AD7c-NTP) expression in patients with Parkinson’s disease (PD). Methods. Fifty patients with PD treated in our hospital from February 2020 to April 2021 were enrolled. The patients were arbitrarily assigned into control group and study group. The former was treated with pramipexole, and the latter was treated with pramipexole combined with NGF. The efficacy, cognitive function, serum inflammatory factors, cortisol levels, serum macrophage migration inhibitory factor (MIF), brain-derived neurotrophic factor (BDNF), urine AD7c-NTP levels, and the incidence of adverse reactions were compared. Results. First of all, the effective rate in the study group was higher compared to the control group (P
ISSN:1748-670X
1748-6718
DOI:10.1155/2022/3398732