Ypsilandrosides U-Y, five new steroidal saponins from Ypsilandrathibetica

Phytochemical reinvestigation on the whole plants of Ypsilandra thibetica obtained four new spirostanol glycosides, named ypsilandrosides U-X ( 1 – 4 ), and one new cholestanol glycoside, named ypsilandroside Y ( 5 ). Their structures have been established by extensive spectroscopic data and chemica...

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Bibliographic Details
Published in:Natural products and bioprospecting 2022-12, Vol.12 (1)
Main Authors: Gao, Wen-Tao, Yu, Ling-Ling, Xie, Jing, Xiao, Long-Gao, Zhang, Shi-Juan, Ma, Wen-Yi, Yan, Huan, Liu, Hai-Yang
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Bioorganic Chemistry
Food Science
Glycosides
Laboratories
Life Sciences
Medicinal Chemistry
Natural products
Original
Original Article
Pharmacology/Toxicology
Plant Biochemistry
Plant Sciences
Platelet aggregation
Saponins
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Summary:Phytochemical reinvestigation on the whole plants of Ypsilandra thibetica obtained four new spirostanol glycosides, named ypsilandrosides U-X ( 1 – 4 ), and one new cholestanol glycoside, named ypsilandroside Y ( 5 ). Their structures have been established by extensive spectroscopic data and chemical methods. Among them, compound 4 is a rare spirostanol glycoside which possesses a novel 5(6 → 7) abeo-steroidal aglycone, while compound 1 is a first spirostanol bisdesmoside attached to C-3 and C-12, respectively, isolated from the genus Ypsilandra . The induced platelet aggregation activity of the isolates was tested. Graphical Abstract
ISSN:2192-2195
2192-2209
DOI:10.1007/s13659-022-00337-0