New α-pyrones from an endophytic fungus, Hypoxylon investiens J2

Four new α-pyrones, hypotiens A-D (1-4), were isolated from a fungal endophyte, J2, harbored in the medicinal plant . Their structures were determined through detailed HRMS and NMR spectroscopic data. Compounds 1-4 are new α-pyrone derivatives containing an unusual dimethyl substitution in the highl...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2019-09, Vol.9 (47), p.27419-27423
Main Authors: Yuan, Chao, Yang, Hong-Xia, Guo, Yu-Hua, Fan, Lin, Zhang, Ying-Bo, Li, Gang
Format: Article
Language:English
Subjects:
Chains
Chemistry
Derivatives
Herbal medicine
NMR
Nuclear magnetic resonance
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Four new α-pyrones, hypotiens A-D (1-4), were isolated from a fungal endophyte, J2, harbored in the medicinal plant . Their structures were determined through detailed HRMS and NMR spectroscopic data. Compounds 1-4 are new α-pyrone derivatives containing an unusual dimethyl substitution in the highly unsaturated side chain. Their plausible biosynthetic pathway was discussed. Biological assay indicated that compounds 1-4 showed no antimicrobial, quorum sensing inhibitory, and cytotoxic activities. The specific side chain in α-pyrone derivatives 1-4 might be responsible for the weak pharmacological activities.
ISSN:2046-2069
2046-2069
DOI:10.1039/c9ra05308e