Eco-friendly polyethylene glycol (PEG-400): a green reaction medium for one-pot, four-component synthesis of novel asymmetrical bis-spirooxindole derivatives at room temperature

PEG-400 has been used as a green and biodegradable polymeric solvent for the one-pot, two-step, multi-component synthesis of novel asymmetrical bis-spirooxindole derivatives by the reaction of -alkyl isatin, isatin derivatives, alkylmalonates and C-H activated carbonyl compounds in the presence of K...

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Bibliographic Details
Published in:RSC advances 2018-01, Vol.8 (4), p.1934-1939
Main Authors: Hasaninejad, Alireza, Beyrati, Maryam
Format: Article
Language:English
Subjects:
Activated carbon
Biodegradability
Carbonyl compounds
Carbonyls
Chemical synthesis
Chemistry
Derivatives
Polyethylene glycol
Room temperature
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Summary:PEG-400 has been used as a green and biodegradable polymeric solvent for the one-pot, two-step, multi-component synthesis of novel asymmetrical bis-spirooxindole derivatives by the reaction of -alkyl isatin, isatin derivatives, alkylmalonates and C-H activated carbonyl compounds in the presence of K CO at room temperature. Using this procedure, all the products were obtained in good to excellent yields.
ISSN:2046-2069
2046-2069
DOI:10.1039/c7ra13133j