An efficient and green synthesis of ferrocenyl-quinoline conjugates via a TsOH-catalyzed three-component reaction in water

An efficient and green synthesis of 4-ferrocenylquinoline derivatives through a TsOH-catalyzed three-component reaction of aromatic aldehydes, amines and ferrocenylacetylene in water has been successfully developed. This strategy is a powerful method for the construction of diverse ferrocenyl-quinol...

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Bibliographic Details
Published in:RSC advances 2018-01, Vol.8 (17), p.9555-9563
Main Authors: Mou, Rui-Qi, Zhao, Mei, Lv, Xue-Xin, Zhang, Sheng-Yan, Guo, Dian-Shun
Format: Article
Language:English
Subjects:
Aldehydes
Amines
Chemical synthesis
Chemistry
Conjugates
Construction methods
Quinoline
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Summary:An efficient and green synthesis of 4-ferrocenylquinoline derivatives through a TsOH-catalyzed three-component reaction of aromatic aldehydes, amines and ferrocenylacetylene in water has been successfully developed. This strategy is a powerful method for the construction of diverse ferrocenyl-quinoline conjugates from simple available starting materials as it minimized the use of metal catalyst and organic solvent in the reaction process. The conjugates feature unique structures and excellent electronic properties. Moreover, a plausible mechanism for this TsOH-catalyzed three-component reaction was proposed and assessed.
ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra01004h