ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2- b ]isoquinoline analogues

An eco-friendly acetylcholine iodide-ethylene glycol (ACI/EG) deep eutectic mixture mediated green protocol has been developed for the synthesis of hitherto unexplored multi-functionalized linear tricyclic spiropyrrolo[1,2- ]isoquinoline analogues. The effects of the synthesized compounds on the ost...

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Bibliographic Details
Published in:RSC advances 2018-01, Vol.8 (29), p.16303-16313
Main Authors: Periyasami, Govindasami, Arumugam, Natarajan, Rahaman, Mostafizur, Kumar, Raju Suresh, Manikandan, Muthurangan, Alfayez, Musaad A, Premnath, Dhanaraj, Aldalbahi, Ali
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Chemistry
Computer simulation
Differentiation
Ethylene glycol
Synthesis
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Summary:An eco-friendly acetylcholine iodide-ethylene glycol (ACI/EG) deep eutectic mixture mediated green protocol has been developed for the synthesis of hitherto unexplored multi-functionalized linear tricyclic spiropyrrolo[1,2- ]isoquinoline analogues. The effects of the synthesized compounds on the osteoblast differentiation of hBMSC-TERT cell lines were investigated and promising results were observed with significant IC values. In addition, molecular modeling simulations were also performed with the 3D structure of BMP-2 to reveal binding interactions and orientations of highly potent spiropyrrolo[1,2- ]isoquinoline analogues.
ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra00646f