Silk Fibroin Hydrogels Could Be Therapeutic Biomaterials for Neurological Diseases

Silk fibroin, a natural macromolecular protein without physiological activity, has been widely used in different fields, such as the regeneration of bones, cartilage, nerves, and other tissues. Due to irrevocable neuronal injury, the treatment and prognosis of neurological diseases need to be invest...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2022, Vol.2022, p.2076680-12
Main Authors: Yang, Chun, Li, Sunao, Huang, Xinqi, Chen, Xueshi, Shan, Haiyan, Chen, Xiping, Tao, Luyang, Zhang, Mingyang
Format: Article
Language:English
Subjects:
Amino acids
Aqueous solutions
Biocompatibility
Biocompatible Materials - therapeutic use
Biomedical materials
Bone and Bones
Carbon dioxide
Dielectric properties
Electric fields
Electrodes
Fibroins - pharmacology
Fibroins - therapeutic use
Humans
Hydrogels
Hydrogels - therapeutic use
Hydrogen bonds
Mechanical properties
Nervous System Diseases - drug therapy
Polymers
Proteins
Review
Solvents
Surfactants
Tissue engineering
Ultrasonic imaging
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Summary:Silk fibroin, a natural macromolecular protein without physiological activity, has been widely used in different fields, such as the regeneration of bones, cartilage, nerves, and other tissues. Due to irrevocable neuronal injury, the treatment and prognosis of neurological diseases need to be investigated. Despite attempts to propel neuroprotective therapeutic approaches, numerous attempts to translate effective therapies for brain disease have been largely unsuccessful. As a good candidate for biomedical applications, hydrogels based on silk fibroin effectively amplify their advantages. The ability of nerve tissue regeneration, inflammation regulation, the slow release of drugs, antioxidative stress, regulation of cell death, and hemostasis could lead to a new approach to treating neurological disorders. In this review, we introduced the preparation of SF hydrogels and then delineated the probable mechanism of silk fibroin in the treatment of neurological diseases. Finally, we showed the application of silk fibroin in neurological diseases.
ISSN:1942-0900
1942-0994
DOI:10.1155/2022/2076680