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Silver-catalyzed direct benzylation of acetanilide: a highly efficient approach to unsymmetrical triarylmethanes

A highly efficient silver-catalyzed dibenzylation of acetanilides by employing the benzhydrol derivatives as the coupling partners to yield triphenylmethane derivatives has been developed. Various functional groups were tolerated, leading to the corresponding products in moderate to good yields. Pre...

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Bibliographic Details
Published in:RSC advances 2018-01, Vol.8 (53), p.30374-30378
Main Authors: Li, Yuting, Zhu, Yan, Tu, Guangliang, Zhang, Jingyu, Zhao, Yingsheng
Format: Article
Language:English
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Summary:A highly efficient silver-catalyzed dibenzylation of acetanilides by employing the benzhydrol derivatives as the coupling partners to yield triphenylmethane derivatives has been developed. Various functional groups were tolerated, leading to the corresponding products in moderate to good yields. Preliminary experimental results indicated that the silver ions activate the arene rings and the strong acid TfOH provides the carbocations.
ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra06780e