Timing and Duration of Axillary Lymph Node Swelling After COVID-19 Vaccination: Japanese Case Report and Literature Review

• Published in: In vivo (Athens) 2022-05, Vol.36 (3), p.1333-1336
• Main Authors: Yoshimoto, Nobuyasu, Yanagi, Akemi, Takayama, Satoru, Sakamoto, Masaki, Tomoda, Keisuke, Ishikawa, Ken, Takura, Kohei, Kawate, Akifumi, Takayama, Shoryu, Yamashita, Masakatsu, Yamamoto, Shinya, Yokoyama, Kioto, Kani, Hisanori
• Format: Article
• Language: English
• Subjects: Aged; Breast Neoplasms - pathology; Case Report; COVID-19; COVID-19 Vaccines - adverse effects; Female; Humans; Japan; Lymph Nodes - pathology; Lymphatic Metastasis - pathology; mRNA Vaccines; Neoplasms, Second Primary - pathology; Vaccination - adverse effects; Vaccines, Synthetic
• ISSN: 0258-851X; 1791-7549
• DOI: 10.21873/invivo.12834

COVID-19 vaccination is now performed in most of the world to limit the spread of the disease. The first mRNA vaccine was approved in clinical settings and has specific side effects including axillary lymph node swelling, which can be misdiagnosed as breast cancer metastasis. The timing of axillary lymph node swelling and its duration are unclear. Here, we present a Japanese case and review of the existing literature. We report the case of a 67-year-old woman with breast calcification. She had regular follow ups in our hospital for this calcification and received ultrasonography of the breast and axilla at every visit. She visited 6 months before having her COVID-19 vaccination, and 7 days and 6 months after the first COVID-19 vaccination. She had a swollen axillary lymph node 7 days after the first vaccination, which although it was improved, remained for 6 months. Axillary lymph node swelling occurred 7 days after vaccination and remained up to 6 months after it.