Preparation and evaluation of poly(ester-urethane) urea/gelatin nanofibers based on different crosslinking strategies for potential applications in vascular tissue engineering

Due to the brittleness of gelatin, the resulting absence of mechanical performance restricts its applications in vascular tissue engineering. In this research, the fabrication of poly(ester-urethane) urea/gelatin (PU75) nanofibers an electrospinning technique, followed by different crosslinking meth...

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Bibliographic Details
Published in:RSC advances 2018-10, Vol.8 (63), p.35917-35927
Main Authors: Wang, Yao, Zhu, Tonghe, Kuang, Haizhu, Sun, Xiaoning, Zhu, Jingjing, Shi, Yu, Wang, Chunsheng, Mo, Xiumei, Lu, Shuyang, Hong, Tao
Format: Article
Language:English
Subjects:
Biocompatibility
Blood vessels
Chemistry
Contact angle
Crosslinking
Fourier transforms
Gelatin
Glutaraldehyde
Infrared reflection
Mechanical properties
Nanofibers
Scaffolds
Scanning electron microscopy
Tissue engineering
Ultrasonic testing
Ureas
Vascular tissue
X ray spectra
X-ray diffraction
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Summary:Due to the brittleness of gelatin, the resulting absence of mechanical performance restricts its applications in vascular tissue engineering. In this research, the fabrication of poly(ester-urethane) urea/gelatin (PU75) nanofibers an electrospinning technique, followed by different crosslinking methods, resulted in the improvement of its mechanical properties. Poly(ester urethane) urea (PEUU) nanofibrous scaffolds and PU75-based nanofibrous scaffolds were characterized using scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, wide-angle X-ray diffraction (WAXRD), a mechanical properties test, a cytocompatibility assay, a hemolysis assay, and a histological analysis. Water contact angle (WCA) tests confirmed that the PU75-GA (PU75 nanofibers crosslinked with glutaraldehyde vapor) nanofibrous scaffold surfaces became more hydrophilic compared with other crosslinked nanofibrous scaffolds. The results show that the PU75-GA nanofibrous scaffold exhibited a combination of excellent mechanical properties, suitable pore diameters, hydrophilic properties, good cytocompatibility, and reliable hemocompatibility. Overall, PU75-GA nanofibers may be a potential scaffold for artificial blood vessel construction.
ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra07123c