Effect of elevated fasting blood glucose level on the 1‐year mortality and sequelae in hospitalized COVID‐19 patients: A bidirectional cohort study

• Published in: Journal of medical virology 2022-07, Vol.94 (7), p.3240-3250
• Main Authors: Chai, Chen, Chen, Kui, Li, Shoupeng, Cheng, Gang, Wang, Wendan, Wang, Hongxiang, Wei, Dunshuang, Peng, Cao, Sun, Qi, Tang, Zehai
• Format: Article
• Language: English
• Subjects: 1‐year mortality; Absorption; Blood; Blood glucose; Blood Glucose - analysis; clinical sequelae; Cohort analysis; Cohort Studies; Complications; Confidence intervals; coronavirus disease 2019; Coronaviruses; COVID-19; COVID-19 - complications; Diabetes; Diabetes Mellitus; Disease Progression; Fasting; fasting blood glucose; Glucose; Hospitalization; Humans; Hyperglycemia; Laboratory testing; Medical prognosis; Mortality; nondiabetics; Patients; Prognosis; Regression analysis; Retrospective Studies; Risk analysis; Risk Factors; Statistical analysis; Viral diseases; Virology
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.27737

To observe the predictive effect of fasting blood glucose (FBG) level on the prognosis, clinical sequelae, and pulmonary absorption in hospitalized coronavirus disease 2019 (COVID‐19) patients with and without a history of diabetes, respectively, and to evaluate the correlation between the dynamic changes of FBG and poor prognosis. In this bidirectional cohort study, we enrolled 2545 hospitalized COVID‐19 patients (439 diabetics and 2106 without a diabetic history) and followed up for 1 year. The patients were divided according to the level of admission FBG. The dynamic changes of FBG were compared between the survival and the death cases. The prediction effect of FBG on 1‐year mortality and sequelae was analyzed. The 1‐year all cause mortality rate and in‐hospital mortality rate of COVID‐19 patients were J‐curve correlated with FBG (p