Nutrition, longevity and disease: From molecular mechanisms to interventions

Diet as a whole, encompassing food composition, calorie intake, and the length and frequency of fasting periods, affects the time span in which health and functional capacity are maintained. Here, we analyze aging and nutrition studies in simple organisms, rodents, monkeys, and humans to link longev...

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Bibliographic Details
Published in:Cell 2022-04, Vol.185 (9), p.1455-1470
Main Authors: Longo, Valter D., Anderson, Rozalyn M.
Format: Article
Language:English
Subjects:
Caloric Restriction
Diet
Longevity
Nutritional Status
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Summary:Diet as a whole, encompassing food composition, calorie intake, and the length and frequency of fasting periods, affects the time span in which health and functional capacity are maintained. Here, we analyze aging and nutrition studies in simple organisms, rodents, monkeys, and humans to link longevity to conserved growth and metabolic pathways and outline their role in aging and age-related disease. We focus on feasible nutritional strategies shown to delay aging and/or prevent diseases through epidemiological, model organism, clinical, and centenarian studies and underline the need to avoid malnourishment and frailty. These findings are integrated to define a longevity diet based on a multi-pillar approach adjusted for age and health status to optimize lifespan and healthspan in humans. Longo and Anderson synthesize and weigh the literature, from molecular mechanisms to epidemiology and spanning yeast to people, about what you should eat, how much you should eat, and when should you eat it to live a long and healthy life.
ISSN:0092-8674
1097-4172
1097-4172
DOI:10.1016/j.cell.2022.04.002