Late-Onset Alcohol Abuse as a Presenting Symptom of Neurodegenerative Diseases

Background: The association between lifetime alcohol abuse and a higher risk to develop dementia is well known. However, it is unknown whether older adults who begin abusing alcohol late in life have an underlying neurodegenerative disease. Objective: Identify the frequency of lifelong alcohol abuse...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Alzheimer's disease 2022-01, Vol.86 (3), p.1073-1080
Main Authors: de Paula França Resende, Elisa, Ketelle, Robin, Karydas, Anna, Allen, Isabel, Grinberg, Lea T., Spina, Salvatore, Seeley, William W., Perry, David C., Miller, Bruce, Naasan, Georges
Format: Article
Language:English
Subjects:
Abuse
Aged
Alcohol
Alcohol abuse
Alcoholism - diagnosis
Alcoholism - epidemiology
Alcohols
Alzheimer Disease - diagnosis
Alzheimer Disease - epidemiology
Alzheimer's disease
Aphasia
Cross-Sectional Studies
Dementia
Dementia disorders
Diagnosis
Drug abuse
Frontotemporal dementia
Frontotemporal Dementia - diagnosis
Frontotemporal Dementia - epidemiology
Humans
Neurodegenerative diseases
Neurodegenerative Diseases - diagnosis
Neurodegenerative Diseases - epidemiology
Neuropsychological Tests
Older people
Patients
Retrospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: The association between lifetime alcohol abuse and a higher risk to develop dementia is well known. However, it is unknown whether older adults who begin abusing alcohol late in life have an underlying neurodegenerative disease. Objective: Identify the frequency of lifelong alcohol abuse (L-AA), late-onset alcohol abuse (LO-AA), and alcohol abuse as a first symptom of dementia (AA-FS) in patients with neurodegenerative diseases. Methods: Cross-sectional retrospective study of patients evaluated at an academic referral center with a clinical diagnosis of behavioral variant frontotemporal dementia (bvFTD), Alzheimer-type dementia (AD), and semantic variant primary progressive aphasia (svPPA) (n = 1,518). The presence of alcohol abuse was screened with the National Alzheimer’s Coordinating Center questionnaire. L-AA was defined as onset
ISSN:1387-2877
1875-8908
DOI:10.3233/JAD-215369