Facile fabrication of water-dispersible nanocomposites based on hexa-peri-hexabenzocoronene and Fe3O4 for dual mode imaging (fluorescent/MR) and drug delivery

The facile fabrication of multifunctional nanocomposites (Fe3O4/HBC@F127) consisting of superparamagnetic Fe3O4 nanoparticles and fluorescent organic hexa-peri-hexabenzocoronene (HBC) molecules incorporated in block copolymer diacylphospholipid–polyethyleneglycol F127 have been demonstrated for dual...

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Bibliographic Details
Published in:RSC advances 2018-01, Vol.8 (71), p.40554-40563
Main Authors: Meng-Meng, Song, Hui-Hui, Xiang, Meng-Yu, Fei, Da-Peng, Lu, Tong-Cui, Jiang, Yong-Qiang, Yu, Liu, Rui, Yu-Xian, Shen
Format: Article
Language:English
Subjects:
Biocompatibility
Block copolymers
Chemistry
Dispersion
Doxorubicin
Drug delivery systems
Fluorescence
Iron oxides
Magnetic resonance imaging
Nanocomposites
Nanoparticles
Photon correlation spectroscopy
Relativity
Toxicity
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Summary:The facile fabrication of multifunctional nanocomposites (Fe3O4/HBC@F127) consisting of superparamagnetic Fe3O4 nanoparticles and fluorescent organic hexa-peri-hexabenzocoronene (HBC) molecules incorporated in block copolymer diacylphospholipid–polyethyleneglycol F127 have been demonstrated for dual mode imaging (fluorescent/MR) and drug delivery. The obtained nanocomposites were water-dispersible, stable and biocompatible, as confirmed by dynamic light scattering (DLS) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Relativity measurements showed a T2 relaxivity (r2) of 214.61 mM−1 s−1, which may be used as T2-weighted MR imaging agents. In vitro imaging studies indicated that the nanocomposites had good MR and fluorescence imaging effects with low cytotoxicity. Besides, the developed nanocomposites could also be applied as drug delivery vehicles. Doxorubicin (DOX) loaded Fe3O4/HBC@F127 nanocomposites significantly inhibited the growth of human hepatoma cells (HepG2). These findings suggested that the facile synthesized multifunctional nanocomposites may be used as a platform for dual mode imaging (both MR and fluorescence) and drug delivery.
ISSN:2046-2069
DOI:10.1039/c8ra08425d