Impact of COVID- 19 pandemic on antidepressants consumptions by wastewater analysis in Turkey

The COVID-19 pandemic has been a major challenge worldwide, forcing countries to take restrictive measures beyond conventional methods in their fight against the spread of the disease. Followingly, many studies have been conducted on the effects of these measures on mental health. Wastewater-based e...

Full description

Saved in:
Bibliographic Details
Published in:The Science of the total environment 2022-09, Vol.838 (Pt 2), p.155916-155916, Article 155916
Main Authors: Yavuz-Guzel, Evsen, Atasoy, Aslı, Gören, İsmail Ethem, Daglioglu, Nebile
Format: Article
Language:English
Subjects:
Antidepressants
Antidepressive Agents - therapeutic use
Chromatography, Liquid
COVID-19
COVID-19 - epidemiology
Drug consumption rate changes
Humans
Pandemics
Tandem Mass Spectrometry
Turkey - epidemiology
Venlafaxine Hydrochloride
Wastewater - analysis
Wastewater-based epidemiology (WBE)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The COVID-19 pandemic has been a major challenge worldwide, forcing countries to take restrictive measures beyond conventional methods in their fight against the spread of the disease. Followingly, many studies have been conducted on the effects of these measures on mental health. Wastewater-based epidemiology (WBE) was used in this study to monitor and estimate changes in antidepressant use under normal conditions (2019) and COVID-19 pandemic conditions (2020). Likewise, this study utilized wastewater-based epidemiology (WBE) to monitor and assess changing trends from the pre-pandemic period (2019) to COVID-19 pandemic conditions in antidepressant use (2020). Wastewater samples were collected from 11 cities in Turkey throughout six sampling periods covering the pre-pandemic and during-pandemic periods (June 2019–December 2020). Then, samples were analyzed via LC-MS/MS method. As a result, we observed that venlafaxine was the drug with the highest concentration (mean ± SD: 103.6 ± 112.1 mg/1000p/day). Moreover, city number 6 presented the highest venlafaxine use and the most dramatic increase during the pandemic period. Finally, this study revealed the potential of WBE to estimate the changing trends in mental health during the ongoing pandemic. [Display omitted] •This study revealed the use of the antidepressant in 10.6 million people.•Antidepressant use increased during the COVID-19 pandemic.•The highest increase was detected in venlafaxine.
ISSN:0048-9697
1879-1026
1879-1026
DOI:10.1016/j.scitotenv.2022.155916