MicroRNAs (miRNAs) in Cardiovascular Complications of Rheumatoid Arthritis (RA): What Is New?

Rheumatoid Arthritis (RA) is among the most prevalent and impactful rheumatologic chronic autoimmune diseases (AIDs) worldwide. Within a framework that recognizes both immunological activation and inflammatory pathways, the exact cause of RA remains unclear. It seems however, that RA is initiated by...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-05, Vol.23 (9), p.5254
Main Authors: Tanase, Daniela Maria, Gosav, Evelina Maria, Petrov, Daniela, Teodorescu, Dan-Stefan, Buliga-Finis, Oana Nicoleta, Ouatu, Anca, Tudorancea, Ionut, Rezus, Elena, Rezus, Ciprian
Format: Article
Language:English
Subjects:
Arthritis
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - genetics
Atherosclerosis
Autoimmune diseases
Biomarkers
Biomarkers - metabolism
Cardiovascular diseases
Cardiovascular Diseases - complications
Cardiovascular Diseases - genetics
Coronaviruses
COVID-19
Heart Diseases - complications
Humans
Immunology
Inflammation
Inflammation - complications
Inflammation - genetics
MicroRNAs
MicroRNAs - metabolism
miRNA
Morbidity
Review
Rheumatoid arthritis
Therapeutic targets
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Summary:Rheumatoid Arthritis (RA) is among the most prevalent and impactful rheumatologic chronic autoimmune diseases (AIDs) worldwide. Within a framework that recognizes both immunological activation and inflammatory pathways, the exact cause of RA remains unclear. It seems however, that RA is initiated by a combination between genetic susceptibility, and environmental triggers, which result in an auto-perpetuating process. The subsequently, systemic inflammation associated with RA is linked with a variety of extra-articular comorbidities, including cardiovascular disease (CVD), resulting in increased mortality and morbidity. Hitherto, vast evidence demonstrated the key role of non-coding RNAs such as microRNAs (miRNAs) in RA, and in RA-CVD related complications. In this descriptive review, we aim to highlight the specific role of miRNAs in autoimmune processes, explicitly on their regulatory roles in the pathogenesis of RA, and its CV consequences, their main role as novel biomarkers, and their possible role as therapeutic targets.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23095254