Persistence of Adverse Drug Reaction-Related Hospitalization Risk Following Discharge

This retrospective cohort study analyzed the administrative hospital records of 91,500 patients with the aim of assessing adverse drug reaction (ADR)-related hospital admission risk after discharge from ADR and non-ADR-related admission. Patients aged ≥18 years with an acute admission to public hosp...

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Bibliographic Details
Published in:International journal of environmental research and public health 2022-05, Vol.19 (9), p.5585
Main Authors: Schmid, Olive, Bereznicki, Bonnie, Peterson, Gregory Mark, Stankovich, Jim, Bereznicki, Luke
Format: Article
Language:English
Subjects:
Adolescent
Adult
Australia
Codes
Comorbidity
Congestive heart failure
Data analysis
Datasets
Drug-Related Side Effects and Adverse Reactions - epidemiology
Hospitalization
Hospitals
Humans
Mortality
Patient admissions
Patients
Retrospective Studies
Risk analysis
Risk Factors
Survival analysis
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Summary:This retrospective cohort study analyzed the administrative hospital records of 91,500 patients with the aim of assessing adverse drug reaction (ADR)-related hospital admission risk after discharge from ADR and non-ADR-related admission. Patients aged ≥18 years with an acute admission to public hospitals in Tasmania, Australia between 2011 and 2015 were followed until May 2017. The index admissions (n = 91,550) were stratified based on whether they were ADR-related (n = 2843, 3.1%) or non-ADR-related (n = 88,707, 96.9%). Survival analysis assessed the post-index ADR-related admission risk using (1) the full dataset, and (2) a matched subset of patients using a propensity score analysis. Logistic regression was used to identify the risk factors for ADR-related admissions within 90 days of post-index discharge. The patients with an ADR-related index admission were almost five times more likely to experience another ADR-related admission within 90 days (p < 0.001). An increased risk persisted for at least 5 years (p < 0.001), which was substantially longer than previously reported. From the matched subset of patients, the risk of ADR-related admission within 90 and 365 days more than doubled in the patients with an ADR-related index admission (p < 0.0001). These admissions were often attributed to the same drug class as the patients’ index ADR-related admission. Cancer was a major risk factor for ADR-related re-hospitalization within 90 days; other factors included heart failure and increasing age.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph19095585