A prospective study to validate the expanded timed get-up-and-go in a population with multiple sclerosis

Background Timed 25-foot walk (T25FW) test serves as gold standard in care of persons with multiple sclerosis (PwMS) and as walking measure of regulatory trials. Objective To validate and determine the clinical utility of Expanded Timed Get-Up and Go (ETGUG) as a disability measure in MS. Methods ET...

Full description

Saved in:
Bibliographic Details
Published in:Multiple sclerosis journal - experimental, translational and clinical translational and clinical, 2022-04, Vol.8 (2), p.20552173221099186-20552173221099186
Main Authors: Jakimovski, Dejan, Kavak, Katelyn S, Zakalik, Karen, Bromley, Lacey, Ozel, Osman, Qutab, Natasha, Eckert, Svetlana P, Kolb, Channa, Weinstock-Guttman, Bianca
Format: Article
Language:English
Subjects:
Multiple sclerosis
Original
Reproducibility
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c2636-397ae885e458306a62f9ccb9f5122c4b634bdeddc0fde2da7a1eb2c789676c5f3
container_end_page 20552173221099186
container_issue 2
container_start_page 20552173221099186
container_title Multiple sclerosis journal - experimental, translational and clinical
container_volume 8
creator Jakimovski, Dejan
Kavak, Katelyn S
Zakalik, Karen
Bromley, Lacey
Ozel, Osman
Qutab, Natasha
Eckert, Svetlana P
Kolb, Channa
Weinstock-Guttman, Bianca
description Background Timed 25-foot walk (T25FW) test serves as gold standard in care of persons with multiple sclerosis (PwMS) and as walking measure of regulatory trials. Objective To validate and determine the clinical utility of Expanded Timed Get-Up and Go (ETGUG) as a disability measure in MS. Methods ETGUG intra-rater and inter-rater reproducibility was determined in 65 PwMS that were examined twice in two centres over 1-week. Values below the 5th and above the 95th percentile were considered minimally detectable change. A longitudinal cohort (32.4 months) of 145 PwMS from New York State MS Consortium (NYSMSC) was used for clinical validation as a predictor of disability worsening measured by Expanded Disability Status Scale (EDSS). Results ETGUG and T25FW had noteworthy intra-rater and inter-rater reproducibility (Cronbach coefficient>0.949). One-week ETGUG difference ranged from 15.07% to −14.84% (5th and 95th percentile). Over the NYSMSC follow-up, PwMS had significant slowing in walking as measured by ETGUG (20.8 to 25.9s, p = 0.009) but not by T25FW. 15% ETGUG worsening had similar ability to predict EDSS worsening when compared to 20% T25FW worsening (AUC 0.596 vs. 0.552). Conclusion Over 32-month follow-up, PwMS experience slowing in ETGUG walking time but not in T25FW. Although the scoring may be more challenging, ETGUG could be more sensitive to change and provide more comprehensive measure of lower extremity performance and ambulation in PwMS.
doi_str_mv 10.1177/20552173221099186
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9102142</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_20552173221099186</sage_id><sourcerecordid>2681715531</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2636-397ae885e458306a62f9ccb9f5122c4b634bdeddc0fde2da7a1eb2c789676c5f3</originalsourceid><addsrcrecordid>eNp1kU9vFSEUxYnR2Kb2A7gxJG7cTOXCADMbk6bxX9LEja4Jw9x5j4Y34MA8228vL6_WqnED5PC7h3O5hLwEdgGg9VvOpOSgBefA-h469YScHrTmID59dD4h5znfMMZAqirCc3IipNTQa3lKtpc0LTEndMXvkeayjne0RLq3wY-2IC1bpHib7DziSIvf1XWDpVlTU6VmE6mfqaUppjXY4uNMf_iypbs1FJ9CNXQBq7_PL8izyYaM5_f7Gfn24f3Xq0_N9ZePn68urxvHlVCN6LXFrpPYyk4wZRWfeueGfpLAuWsHJdqhJhkdm0bko9UWcOBOd73SyslJnJF3R9-0DjWsw7ksNpi0-J1d7ky03vx5M_ut2cS96YFxaHk1eHNvsMTvK-Zidj47DMHOGNdsuFISWCtaqOjrv9CbuC5zba9SHWiQUhwoOFKufkRecHoIA8wcRmn-GWWtefW4i4eKX4OrwMURyHaDv5_9v-NPWJynqQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2681715531</pqid></control><display><type>article</type><title>A prospective study to validate the expanded timed get-up-and-go in a population with multiple sclerosis</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Jakimovski, Dejan ; Kavak, Katelyn S ; Zakalik, Karen ; Bromley, Lacey ; Ozel, Osman ; Qutab, Natasha ; Eckert, Svetlana P ; Kolb, Channa ; Weinstock-Guttman, Bianca</creator><creatorcontrib>Jakimovski, Dejan ; Kavak, Katelyn S ; Zakalik, Karen ; Bromley, Lacey ; Ozel, Osman ; Qutab, Natasha ; Eckert, Svetlana P ; Kolb, Channa ; Weinstock-Guttman, Bianca</creatorcontrib><description>Background Timed 25-foot walk (T25FW) test serves as gold standard in care of persons with multiple sclerosis (PwMS) and as walking measure of regulatory trials. Objective To validate and determine the clinical utility of Expanded Timed Get-Up and Go (ETGUG) as a disability measure in MS. Methods ETGUG intra-rater and inter-rater reproducibility was determined in 65 PwMS that were examined twice in two centres over 1-week. Values below the 5th and above the 95th percentile were considered minimally detectable change. A longitudinal cohort (32.4 months) of 145 PwMS from New York State MS Consortium (NYSMSC) was used for clinical validation as a predictor of disability worsening measured by Expanded Disability Status Scale (EDSS). Results ETGUG and T25FW had noteworthy intra-rater and inter-rater reproducibility (Cronbach coefficient&gt;0.949). One-week ETGUG difference ranged from 15.07% to −14.84% (5th and 95th percentile). Over the NYSMSC follow-up, PwMS had significant slowing in walking as measured by ETGUG (20.8 to 25.9s, p = 0.009) but not by T25FW. 15% ETGUG worsening had similar ability to predict EDSS worsening when compared to 20% T25FW worsening (AUC 0.596 vs. 0.552). Conclusion Over 32-month follow-up, PwMS experience slowing in ETGUG walking time but not in T25FW. Although the scoring may be more challenging, ETGUG could be more sensitive to change and provide more comprehensive measure of lower extremity performance and ambulation in PwMS.</description><identifier>ISSN: 2055-2173</identifier><identifier>EISSN: 2055-2173</identifier><identifier>DOI: 10.1177/20552173221099186</identifier><identifier>PMID: 35571975</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Multiple sclerosis ; Original ; Reproducibility</subject><ispartof>Multiple sclerosis journal - experimental, translational and clinical, 2022-04, Vol.8 (2), p.20552173221099186-20552173221099186</ispartof><rights>The Author(s), 2022</rights><rights>The Author(s), 2022.</rights><rights>The Author(s), 2022. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s), 2022 2022 SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2636-397ae885e458306a62f9ccb9f5122c4b634bdeddc0fde2da7a1eb2c789676c5f3</cites><orcidid>0000-0002-6119-1387 ; 0000-0002-9236-3161 ; 0000-0001-6732-151X ; 0000-0001-7114-4958</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102142/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2681715531?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35571975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jakimovski, Dejan</creatorcontrib><creatorcontrib>Kavak, Katelyn S</creatorcontrib><creatorcontrib>Zakalik, Karen</creatorcontrib><creatorcontrib>Bromley, Lacey</creatorcontrib><creatorcontrib>Ozel, Osman</creatorcontrib><creatorcontrib>Qutab, Natasha</creatorcontrib><creatorcontrib>Eckert, Svetlana P</creatorcontrib><creatorcontrib>Kolb, Channa</creatorcontrib><creatorcontrib>Weinstock-Guttman, Bianca</creatorcontrib><title>A prospective study to validate the expanded timed get-up-and-go in a population with multiple sclerosis</title><title>Multiple sclerosis journal - experimental, translational and clinical</title><addtitle>Mult Scler J Exp Transl Clin</addtitle><description>Background Timed 25-foot walk (T25FW) test serves as gold standard in care of persons with multiple sclerosis (PwMS) and as walking measure of regulatory trials. Objective To validate and determine the clinical utility of Expanded Timed Get-Up and Go (ETGUG) as a disability measure in MS. Methods ETGUG intra-rater and inter-rater reproducibility was determined in 65 PwMS that were examined twice in two centres over 1-week. Values below the 5th and above the 95th percentile were considered minimally detectable change. A longitudinal cohort (32.4 months) of 145 PwMS from New York State MS Consortium (NYSMSC) was used for clinical validation as a predictor of disability worsening measured by Expanded Disability Status Scale (EDSS). Results ETGUG and T25FW had noteworthy intra-rater and inter-rater reproducibility (Cronbach coefficient&gt;0.949). One-week ETGUG difference ranged from 15.07% to −14.84% (5th and 95th percentile). Over the NYSMSC follow-up, PwMS had significant slowing in walking as measured by ETGUG (20.8 to 25.9s, p = 0.009) but not by T25FW. 15% ETGUG worsening had similar ability to predict EDSS worsening when compared to 20% T25FW worsening (AUC 0.596 vs. 0.552). Conclusion Over 32-month follow-up, PwMS experience slowing in ETGUG walking time but not in T25FW. Although the scoring may be more challenging, ETGUG could be more sensitive to change and provide more comprehensive measure of lower extremity performance and ambulation in PwMS.</description><subject>Multiple sclerosis</subject><subject>Original</subject><subject>Reproducibility</subject><issn>2055-2173</issn><issn>2055-2173</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>PIMPY</sourceid><recordid>eNp1kU9vFSEUxYnR2Kb2A7gxJG7cTOXCADMbk6bxX9LEja4Jw9x5j4Y34MA8228vL6_WqnED5PC7h3O5hLwEdgGg9VvOpOSgBefA-h469YScHrTmID59dD4h5znfMMZAqirCc3IipNTQa3lKtpc0LTEndMXvkeayjne0RLq3wY-2IC1bpHib7DziSIvf1XWDpVlTU6VmE6mfqaUppjXY4uNMf_iypbs1FJ9CNXQBq7_PL8izyYaM5_f7Gfn24f3Xq0_N9ZePn68urxvHlVCN6LXFrpPYyk4wZRWfeueGfpLAuWsHJdqhJhkdm0bko9UWcOBOd73SyslJnJF3R9-0DjWsw7ksNpi0-J1d7ky03vx5M_ut2cS96YFxaHk1eHNvsMTvK-Zidj47DMHOGNdsuFISWCtaqOjrv9CbuC5zba9SHWiQUhwoOFKufkRecHoIA8wcRmn-GWWtefW4i4eKX4OrwMURyHaDv5_9v-NPWJynqQ</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Jakimovski, Dejan</creator><creator>Kavak, Katelyn S</creator><creator>Zakalik, Karen</creator><creator>Bromley, Lacey</creator><creator>Ozel, Osman</creator><creator>Qutab, Natasha</creator><creator>Eckert, Svetlana P</creator><creator>Kolb, Channa</creator><creator>Weinstock-Guttman, Bianca</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6119-1387</orcidid><orcidid>https://orcid.org/0000-0002-9236-3161</orcidid><orcidid>https://orcid.org/0000-0001-6732-151X</orcidid><orcidid>https://orcid.org/0000-0001-7114-4958</orcidid></search><sort><creationdate>202204</creationdate><title>A prospective study to validate the expanded timed get-up-and-go in a population with multiple sclerosis</title><author>Jakimovski, Dejan ; Kavak, Katelyn S ; Zakalik, Karen ; Bromley, Lacey ; Ozel, Osman ; Qutab, Natasha ; Eckert, Svetlana P ; Kolb, Channa ; Weinstock-Guttman, Bianca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2636-397ae885e458306a62f9ccb9f5122c4b634bdeddc0fde2da7a1eb2c789676c5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Multiple sclerosis</topic><topic>Original</topic><topic>Reproducibility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jakimovski, Dejan</creatorcontrib><creatorcontrib>Kavak, Katelyn S</creatorcontrib><creatorcontrib>Zakalik, Karen</creatorcontrib><creatorcontrib>Bromley, Lacey</creatorcontrib><creatorcontrib>Ozel, Osman</creatorcontrib><creatorcontrib>Qutab, Natasha</creatorcontrib><creatorcontrib>Eckert, Svetlana P</creatorcontrib><creatorcontrib>Kolb, Channa</creatorcontrib><creatorcontrib>Weinstock-Guttman, Bianca</creatorcontrib><collection>SAGE Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Multiple sclerosis journal - experimental, translational and clinical</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jakimovski, Dejan</au><au>Kavak, Katelyn S</au><au>Zakalik, Karen</au><au>Bromley, Lacey</au><au>Ozel, Osman</au><au>Qutab, Natasha</au><au>Eckert, Svetlana P</au><au>Kolb, Channa</au><au>Weinstock-Guttman, Bianca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective study to validate the expanded timed get-up-and-go in a population with multiple sclerosis</atitle><jtitle>Multiple sclerosis journal - experimental, translational and clinical</jtitle><addtitle>Mult Scler J Exp Transl Clin</addtitle><date>2022-04</date><risdate>2022</risdate><volume>8</volume><issue>2</issue><spage>20552173221099186</spage><epage>20552173221099186</epage><pages>20552173221099186-20552173221099186</pages><issn>2055-2173</issn><eissn>2055-2173</eissn><abstract>Background Timed 25-foot walk (T25FW) test serves as gold standard in care of persons with multiple sclerosis (PwMS) and as walking measure of regulatory trials. Objective To validate and determine the clinical utility of Expanded Timed Get-Up and Go (ETGUG) as a disability measure in MS. Methods ETGUG intra-rater and inter-rater reproducibility was determined in 65 PwMS that were examined twice in two centres over 1-week. Values below the 5th and above the 95th percentile were considered minimally detectable change. A longitudinal cohort (32.4 months) of 145 PwMS from New York State MS Consortium (NYSMSC) was used for clinical validation as a predictor of disability worsening measured by Expanded Disability Status Scale (EDSS). Results ETGUG and T25FW had noteworthy intra-rater and inter-rater reproducibility (Cronbach coefficient&gt;0.949). One-week ETGUG difference ranged from 15.07% to −14.84% (5th and 95th percentile). Over the NYSMSC follow-up, PwMS had significant slowing in walking as measured by ETGUG (20.8 to 25.9s, p = 0.009) but not by T25FW. 15% ETGUG worsening had similar ability to predict EDSS worsening when compared to 20% T25FW worsening (AUC 0.596 vs. 0.552). Conclusion Over 32-month follow-up, PwMS experience slowing in ETGUG walking time but not in T25FW. Although the scoring may be more challenging, ETGUG could be more sensitive to change and provide more comprehensive measure of lower extremity performance and ambulation in PwMS.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>35571975</pmid><doi>10.1177/20552173221099186</doi><orcidid>https://orcid.org/0000-0002-6119-1387</orcidid><orcidid>https://orcid.org/0000-0002-9236-3161</orcidid><orcidid>https://orcid.org/0000-0001-6732-151X</orcidid><orcidid>https://orcid.org/0000-0001-7114-4958</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2055-2173
ispartof Multiple sclerosis journal - experimental, translational and clinical, 2022-04, Vol.8 (2), p.20552173221099186-20552173221099186
issn 2055-2173
2055-2173
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9102142
source Publicly Available Content Database; PubMed Central
subjects Multiple sclerosis
Original
Reproducibility
title A prospective study to validate the expanded timed get-up-and-go in a population with multiple sclerosis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T01%3A08%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20prospective%20study%20to%20validate%20the%20expanded%20timed%20get-up-and-go%20in%20a%20population%20with%20multiple%20sclerosis&rft.jtitle=Multiple%20sclerosis%20journal%20-%20experimental,%20translational%20and%20clinical&rft.au=Jakimovski,%20Dejan&rft.date=2022-04&rft.volume=8&rft.issue=2&rft.spage=20552173221099186&rft.epage=20552173221099186&rft.pages=20552173221099186-20552173221099186&rft.issn=2055-2173&rft.eissn=2055-2173&rft_id=info:doi/10.1177/20552173221099186&rft_dat=%3Cproquest_pubme%3E2681715531%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c2636-397ae885e458306a62f9ccb9f5122c4b634bdeddc0fde2da7a1eb2c789676c5f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2681715531&rft_id=info:pmid/35571975&rft_sage_id=10.1177_20552173221099186&rfr_iscdi=true