Case report: A novel cause of acute liver failure in children: A combination of human herpesvirus‐6 infection and homozygous mutation in NBAS gene

Etiologies of acute liver failure in children can be multiple factors including virus infection, drug‐induced damage, and different pathogens. Next‐generation sequencing (NGS) is an emerging method for pan‐pathogen screening. Here we reported a case of acute liver failure in a 15‐month‐old male, usi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical laboratory analysis 2022-05, Vol.36 (5), p.e24343-n/a
Main Authors: Cheng, Ying, Xia, Zhi, Huang, Chengjiao, Xu, Hui
Format: Article
Language:English
Subjects:
Acids
acute liver failure
Case Report
Case reports
Children
Coma
Genetic testing
Genomes
human herpesvirus‐6
Laboratories
Liver diseases
Liver failure
Lymphocytes
Mutation
NBAS
Neuroblastoma
Nonsteroidal anti-inflammatory drugs
Pathogens
Pediatrics
Proteins
Severe acute respiratory syndrome coronavirus 2
Software packages
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Etiologies of acute liver failure in children can be multiple factors including virus infection, drug‐induced damage, and different pathogens. Next‐generation sequencing (NGS) is an emerging method for pan‐pathogen screening. Here we reported a case of acute liver failure in a 15‐month‐old male, using NGS and gene sequencing to determine the cause of acute liver failure may be caused by pathogens, drug‐induction and pathogenic variant gene.
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.24343