Adiponectin, A-FABP and FGF-19 Levels in Women with Early Diagnosed Gestational Diabetes

Background: Adiponectin, adipocyte fatty acid-binding protein (A-FABP), and fibroblast growth factor-19 (FGF-19) belong to proteins involved in glucose metabolism regulation. The aims of the study were to compare the plasma levels of these proteins in women with early diagnosed gestational diabetes...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical medicine 2022-04, Vol.11 (9), p.2417
Main Authors: Karasek, David, Krystynik, Ondrej, Kucerova, Veronika, Macakova, Dominika, Cibickova, Lubica, Schovanek, Jan, Haluzik, Martin
Format: Article
Language:English
Subjects:
Adipocytes
Antibodies
Body fat
Body mass index
Clinical medicine
Fatty acids
Gestational diabetes
Glucose
Homeostasis
Insulin resistance
Laboratories
Metabolism
Peptides
Pregnancy
Proteins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c3247-1987cff73930b1f28aab363b9eba12e8e821cf4180a52680ea228be81f744b103
cites cdi_FETCH-LOGICAL-c3247-1987cff73930b1f28aab363b9eba12e8e821cf4180a52680ea228be81f744b103
container_end_page
container_issue 9
container_start_page 2417
container_title Journal of clinical medicine
container_volume 11
creator Karasek, David
Krystynik, Ondrej
Kucerova, Veronika
Macakova, Dominika
Cibickova, Lubica
Schovanek, Jan
Haluzik, Martin
description Background: Adiponectin, adipocyte fatty acid-binding protein (A-FABP), and fibroblast growth factor-19 (FGF-19) belong to proteins involved in glucose metabolism regulation. The aims of the study were to compare the plasma levels of these proteins in women with early diagnosed gestational diabetes mellitus (GDM) to those in healthy controls and to investigate their changes during pregnancy after early intervention. Methods: The study was undertaken as a case-control study. Early GDM diagnosis was based on repeated fasting plasma glucose ≥5.1 and
doi_str_mv 10.3390/jcm11092417
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9103722</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2664801984</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3247-1987cff73930b1f28aab363b9eba12e8e821cf4180a52680ea228be81f744b103</originalsourceid><addsrcrecordid>eNpdkc1LAzEQxYMoVtSTdwl4EXQ1X91kL0KtbRUKelD0FrLbWU3ZTepmW_G_N9VaqrlMSH7z5g0PoSNKLjjPyOW0qCklGRNUbqE9RqRMCFd8e-PeQYchTEk8SglG5S7q8G43TbuC7aGX3sTOvIOite4c95Jh7_oBGzfBw9EwoRkewwKqgK3Dz74Ghz9s-4YHpqk-8Y01r84HmOARhNa01jtTLV9zaCEcoJ3SVAEOV3UfPQ0Hj_3bZHw_uuv3xknBmZBxhJJFWUqecZLTkiljcp7yPIPcUAYKFKNFKagipstSRcAwpnJQtJRC5JTwfXT1ozub5zVMCnBtYyo9a2xtmk_tjdV_f5x9069-obPYLBmLAqcrgca_z-MmurahgKoyDvw8aJamQpHoU0T05B869fMmbv1NccIkI0tHZz9U0fgQGijXZijRy9D0RmiRPt70v2Z_I-Jf40qPhQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2663027200</pqid></control><display><type>article</type><title>Adiponectin, A-FABP and FGF-19 Levels in Women with Early Diagnosed Gestational Diabetes</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Karasek, David ; Krystynik, Ondrej ; Kucerova, Veronika ; Macakova, Dominika ; Cibickova, Lubica ; Schovanek, Jan ; Haluzik, Martin</creator><creatorcontrib>Karasek, David ; Krystynik, Ondrej ; Kucerova, Veronika ; Macakova, Dominika ; Cibickova, Lubica ; Schovanek, Jan ; Haluzik, Martin</creatorcontrib><description>Background: Adiponectin, adipocyte fatty acid-binding protein (A-FABP), and fibroblast growth factor-19 (FGF-19) belong to proteins involved in glucose metabolism regulation. The aims of the study were to compare the plasma levels of these proteins in women with early diagnosed gestational diabetes mellitus (GDM) to those in healthy controls and to investigate their changes during pregnancy after early intervention. Methods: The study was undertaken as a case-control study. Early GDM diagnosis was based on repeated fasting plasma glucose ≥5.1 and &lt;7.0 mmol/L during the first trimester of pregnancy and exclusion of overt diabetes. Age-matched controls comprised healthy pregnant and non-pregnant women. In addition to adipokines, clinical parameters and measures of glucose control were assessed. Results: Women with GDM (n = 23) had significantly lower adiponectin and higher A-FABP levels compared to healthy pregnant (n = 29) or non-pregnant (n = 25) controls, while no significant differences in FGF-19 between the groups were found. The therapeutic intervention shifted adiponectin and A-FABP levels in GDM women towards concentrations of healthy pregnant controls. Adipokines were associated with visceral adiposity and glucose control. Conclusion: Women with GDM showed altered adipokine production even in the first trimester of pregnancy. Early therapeutic intervention not only improved glucose control but also normalized impaired adipokine production.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11092417</identifier><identifier>PMID: 35566542</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adipocytes ; Antibodies ; Body fat ; Body mass index ; Clinical medicine ; Fatty acids ; Gestational diabetes ; Glucose ; Homeostasis ; Insulin resistance ; Laboratories ; Metabolism ; Peptides ; Pregnancy ; Proteins</subject><ispartof>Journal of clinical medicine, 2022-04, Vol.11 (9), p.2417</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3247-1987cff73930b1f28aab363b9eba12e8e821cf4180a52680ea228be81f744b103</citedby><cites>FETCH-LOGICAL-c3247-1987cff73930b1f28aab363b9eba12e8e821cf4180a52680ea228be81f744b103</cites><orcidid>0000-0002-9309-4952 ; 0000-0002-2944-7178</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2663027200/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2663027200?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35566542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karasek, David</creatorcontrib><creatorcontrib>Krystynik, Ondrej</creatorcontrib><creatorcontrib>Kucerova, Veronika</creatorcontrib><creatorcontrib>Macakova, Dominika</creatorcontrib><creatorcontrib>Cibickova, Lubica</creatorcontrib><creatorcontrib>Schovanek, Jan</creatorcontrib><creatorcontrib>Haluzik, Martin</creatorcontrib><title>Adiponectin, A-FABP and FGF-19 Levels in Women with Early Diagnosed Gestational Diabetes</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Background: Adiponectin, adipocyte fatty acid-binding protein (A-FABP), and fibroblast growth factor-19 (FGF-19) belong to proteins involved in glucose metabolism regulation. The aims of the study were to compare the plasma levels of these proteins in women with early diagnosed gestational diabetes mellitus (GDM) to those in healthy controls and to investigate their changes during pregnancy after early intervention. Methods: The study was undertaken as a case-control study. Early GDM diagnosis was based on repeated fasting plasma glucose ≥5.1 and &lt;7.0 mmol/L during the first trimester of pregnancy and exclusion of overt diabetes. Age-matched controls comprised healthy pregnant and non-pregnant women. In addition to adipokines, clinical parameters and measures of glucose control were assessed. Results: Women with GDM (n = 23) had significantly lower adiponectin and higher A-FABP levels compared to healthy pregnant (n = 29) or non-pregnant (n = 25) controls, while no significant differences in FGF-19 between the groups were found. The therapeutic intervention shifted adiponectin and A-FABP levels in GDM women towards concentrations of healthy pregnant controls. Adipokines were associated with visceral adiposity and glucose control. Conclusion: Women with GDM showed altered adipokine production even in the first trimester of pregnancy. Early therapeutic intervention not only improved glucose control but also normalized impaired adipokine production.</description><subject>Adipocytes</subject><subject>Antibodies</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Clinical medicine</subject><subject>Fatty acids</subject><subject>Gestational diabetes</subject><subject>Glucose</subject><subject>Homeostasis</subject><subject>Insulin resistance</subject><subject>Laboratories</subject><subject>Metabolism</subject><subject>Peptides</subject><subject>Pregnancy</subject><subject>Proteins</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkc1LAzEQxYMoVtSTdwl4EXQ1X91kL0KtbRUKelD0FrLbWU3ZTepmW_G_N9VaqrlMSH7z5g0PoSNKLjjPyOW0qCklGRNUbqE9RqRMCFd8e-PeQYchTEk8SglG5S7q8G43TbuC7aGX3sTOvIOite4c95Jh7_oBGzfBw9EwoRkewwKqgK3Dz74Ghz9s-4YHpqk-8Y01r84HmOARhNa01jtTLV9zaCEcoJ3SVAEOV3UfPQ0Hj_3bZHw_uuv3xknBmZBxhJJFWUqecZLTkiljcp7yPIPcUAYKFKNFKagipstSRcAwpnJQtJRC5JTwfXT1ozub5zVMCnBtYyo9a2xtmk_tjdV_f5x9069-obPYLBmLAqcrgca_z-MmurahgKoyDvw8aJamQpHoU0T05B869fMmbv1NccIkI0tHZz9U0fgQGijXZijRy9D0RmiRPt70v2Z_I-Jf40qPhQ</recordid><startdate>20220425</startdate><enddate>20220425</enddate><creator>Karasek, David</creator><creator>Krystynik, Ondrej</creator><creator>Kucerova, Veronika</creator><creator>Macakova, Dominika</creator><creator>Cibickova, Lubica</creator><creator>Schovanek, Jan</creator><creator>Haluzik, Martin</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9309-4952</orcidid><orcidid>https://orcid.org/0000-0002-2944-7178</orcidid></search><sort><creationdate>20220425</creationdate><title>Adiponectin, A-FABP and FGF-19 Levels in Women with Early Diagnosed Gestational Diabetes</title><author>Karasek, David ; Krystynik, Ondrej ; Kucerova, Veronika ; Macakova, Dominika ; Cibickova, Lubica ; Schovanek, Jan ; Haluzik, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3247-1987cff73930b1f28aab363b9eba12e8e821cf4180a52680ea228be81f744b103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adipocytes</topic><topic>Antibodies</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Clinical medicine</topic><topic>Fatty acids</topic><topic>Gestational diabetes</topic><topic>Glucose</topic><topic>Homeostasis</topic><topic>Insulin resistance</topic><topic>Laboratories</topic><topic>Metabolism</topic><topic>Peptides</topic><topic>Pregnancy</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karasek, David</creatorcontrib><creatorcontrib>Krystynik, Ondrej</creatorcontrib><creatorcontrib>Kucerova, Veronika</creatorcontrib><creatorcontrib>Macakova, Dominika</creatorcontrib><creatorcontrib>Cibickova, Lubica</creatorcontrib><creatorcontrib>Schovanek, Jan</creatorcontrib><creatorcontrib>Haluzik, Martin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karasek, David</au><au>Krystynik, Ondrej</au><au>Kucerova, Veronika</au><au>Macakova, Dominika</au><au>Cibickova, Lubica</au><au>Schovanek, Jan</au><au>Haluzik, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adiponectin, A-FABP and FGF-19 Levels in Women with Early Diagnosed Gestational Diabetes</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2022-04-25</date><risdate>2022</risdate><volume>11</volume><issue>9</issue><spage>2417</spage><pages>2417-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Background: Adiponectin, adipocyte fatty acid-binding protein (A-FABP), and fibroblast growth factor-19 (FGF-19) belong to proteins involved in glucose metabolism regulation. The aims of the study were to compare the plasma levels of these proteins in women with early diagnosed gestational diabetes mellitus (GDM) to those in healthy controls and to investigate their changes during pregnancy after early intervention. Methods: The study was undertaken as a case-control study. Early GDM diagnosis was based on repeated fasting plasma glucose ≥5.1 and &lt;7.0 mmol/L during the first trimester of pregnancy and exclusion of overt diabetes. Age-matched controls comprised healthy pregnant and non-pregnant women. In addition to adipokines, clinical parameters and measures of glucose control were assessed. Results: Women with GDM (n = 23) had significantly lower adiponectin and higher A-FABP levels compared to healthy pregnant (n = 29) or non-pregnant (n = 25) controls, while no significant differences in FGF-19 between the groups were found. The therapeutic intervention shifted adiponectin and A-FABP levels in GDM women towards concentrations of healthy pregnant controls. Adipokines were associated with visceral adiposity and glucose control. Conclusion: Women with GDM showed altered adipokine production even in the first trimester of pregnancy. Early therapeutic intervention not only improved glucose control but also normalized impaired adipokine production.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35566542</pmid><doi>10.3390/jcm11092417</doi><orcidid>https://orcid.org/0000-0002-9309-4952</orcidid><orcidid>https://orcid.org/0000-0002-2944-7178</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2077-0383
ispartof Journal of clinical medicine, 2022-04, Vol.11 (9), p.2417
issn 2077-0383
2077-0383
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9103722
source Publicly Available Content Database; PubMed Central
subjects Adipocytes
Antibodies
Body fat
Body mass index
Clinical medicine
Fatty acids
Gestational diabetes
Glucose
Homeostasis
Insulin resistance
Laboratories
Metabolism
Peptides
Pregnancy
Proteins
title Adiponectin, A-FABP and FGF-19 Levels in Women with Early Diagnosed Gestational Diabetes
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T20%3A01%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adiponectin,%20A-FABP%20and%20FGF-19%20Levels%20in%20Women%20with%20Early%20Diagnosed%20Gestational%20Diabetes&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Karasek,%20David&rft.date=2022-04-25&rft.volume=11&rft.issue=9&rft.spage=2417&rft.pages=2417-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm11092417&rft_dat=%3Cproquest_pubme%3E2664801984%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3247-1987cff73930b1f28aab363b9eba12e8e821cf4180a52680ea228be81f744b103%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2663027200&rft_id=info:pmid/35566542&rfr_iscdi=true