Increased Risk to Develop Hypertension and Carotid Plaques in Patients with Long-Lasting Helicobacter pylori Gastritis

infection has been reported to be positively associated with hypertension, although with conflicting results. In this study, the relationship between infection and hypertension, as well as atherosclerotic carotid lesions, was analyzed. Clinical records of patients referred to undergo upper endoscopy...

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Bibliographic Details
Published in:Journal of clinical medicine 2022-04, Vol.11 (9), p.2282
Main Authors: Dore, Maria Pina, Saba, Pier Sergio, Tomassini, Giulia, Niolu, Caterina, Monaco, Marco, Pes, Giovanni Mario
Format: Article
Language:English
Subjects:
Atherosclerosis
Bacteria
Bacterial infections
Blood pressure
Cardiovascular disease
Carotid arteries
Clinical medicine
Diabetes
Endoscopy
Hypertension
Infections
Obesity
Patients
Risk factors
Smoking
Ultrasonic imaging
Veins & arteries
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Summary:infection has been reported to be positively associated with hypertension, although with conflicting results. In this study, the relationship between infection and hypertension, as well as atherosclerotic carotid lesions, was analyzed. Clinical records of patients referred to undergo upper endoscopy and gastric biopsy were retrieved. Information regarding the presence of infection with atrophy/metaplasia/dysplasia (interpreted as a long-lasting infection), and current or past infection was collected, as well as demographic variables, smoking habits, body mass index (BMI), dyslipidemia, diabetes, hypertension, presence of carotid lesions, and current treatment, and analyzed by multivariable regression models. A total of 7152 clinical records from patients older than 30 years (63.4% women) were available for the study. Hypertension was present in 2039 (28.5%) patients and the risk was significantly increased in those with long-lasting infection after adjusting for age decades, sex, BMI, cigarette smoking, diabetes, and dyslipidemia (OR 1.17, 95% CI 1.02-1.35). In addition, the long-lasting infection was an independent risk for carotid plaques (OR 2.15, 95% CI 1.14-4.09). Our retrospective study demonstrated that long-lasting infection is an independent risk factor for hypertension and the presence of carotid lesions after adjusting for potential confounders, although further validation our findings is needed from prospective studies.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11092282