Benefits of diffusion-weighted imaging in pediatric acute osteoarticular infections

• Published in: Pediatric radiology 2022-05, Vol.52 (6), p.1086-1094
• Main Authors: Habre, Céline, Botti, Paul, Laurent, Méryle, Ceroni, Dimitri, Toso, Seema, Hanquinet, Sylviane
• Format: Article
• Language: English
• Subjects: Abscesses; Arthritis; Biomedical materials; Bones; Children; Diagnosis; Diagnostic systems; Equivalence; Femur; Gadolinium; Image enhancement; Imaging; Infections; Magnetic resonance imaging; Medical imaging; Medicine; Medicine & Public Health; Neuroradiology; Nuclear Medicine; Oncology; Original; Original Article; Osteomyelitis; Pediatrics; Radiology; Sensitivity; Soft tissues; Ultrasound
• ISSN: 0301-0449; 1432-1998
• DOI: 10.1007/s00247-022-05329-3

Background Contrast-enhanced magnetic resonance imaging (MRI) is recommended for the diagnosis of acute osteoarticular infections in children. Diffusion-weighted imaging (DWI) may be an alternative to the injection of gadolinium. Objective To evaluate unenhanced MRI with DWI in comparison to contrast-enhanced MRI for the diagnostic work-up of acute osteoarticular infections in children. Materials and methods This retrospective study included 36 children (age range: 7 months-12 years) with extra-spinal osteoarticular infections and MRI performed within 24 h of admission. MRI protocol included short tau inversion recovery (STIR), water-only T2 Dixon, T1, DWI, and gadolinium-enhanced T1 sequences. Two readers reviewed three sets of images: 1) unenhanced sequences, 2) unenhanced sequences with DWI and 3) unenhanced followed by contrast-enhanced sequences (reference standard). Sensitivity and specificity of sets 1 and 2 were compared to set 3 and assessed to identify osteoarticular infections: osteomyelitis (long bones, metaphyseal equivalents), septic arthritis and abscess (soft tissues, bone). Results All 14 cases of osteomyelitis in the metaphyses and diaphyses of long bones and all 27 cases of septic arthritis were identified by unenhanced sequences, but 4/16 abscesses were missed. For the diagnosis of abscess, DWI increased sensitivity to 100%. Among the 18 osteomyelitis in metaphyseal equivalents, 4 femoral head chondroepiphyses were identified by contrast-enhanced sequences only. Conclusion MRI for suspected pediatric acute osteoarticular infections is the best diagnostic modality to guide patient management. An unenhanced protocol with DWI may be an alternative to a contrast-based protocol, even in the presence of an abscess. However, gadolinium remains necessary to assess for chondroepiphyseal involvement of the femoral head.