Phlorotannins–bioactivity and extraction perspectives

Phlorotannins, a seaweed based class of polyphenolic compounds, have proven to possess potential bioactivities such as antioxidant, antimicrobial, anti-allergic, anti-diabetic, anti-inflammatory, anti-cancerous, neuroprotection etc. These bioactivities have further increased demand globally and sust...

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Bibliographic Details
Published in:Journal of applied phycology 2022-08, Vol.34 (4), p.2173-2185
Main Authors: Kumar, Lekshmi R. G., Paul, Preethy Treesa, Anas, K. K., Tejpal, C. S., Chatterjee, N. S., Anupama, T. K., Mathew, Suseela, Ravishankar, C. N.
Format: Article
Language:English
Subjects:
Algae
Analytical methods
Antiinfectives and antibacterials
Antioxidants
Biological activity
Biomedical and Life Sciences
Commercialization
Diabetes
Diabetes mellitus
Ecology
Edema
Fisheries
Freshwater & Marine Ecology
Functional foods & nutraceuticals
Histamine
Immunology
In vivo methods and tests
Inflammation
Leukemia
Life Sciences
Magnetic resonance spectroscopy
Marketing
Mass spectrometry
Mass spectroscopy
Molecular weight
Neuroprotection
NMR
NMR spectroscopy
Nuclear magnetic resonance
Plant Physiology
Plant Sciences
Polymerization
Polyphenols
Radiation
Seaweeds
Solvent extraction
Supercritical fluids
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Summary:Phlorotannins, a seaweed based class of polyphenolic compounds, have proven to possess potential bioactivities such as antioxidant, antimicrobial, anti-allergic, anti-diabetic, anti-inflammatory, anti-cancerous, neuroprotection etc. These bioactivities have further increased demand globally and sustainable techniques such as supercritical fluid extraction, microwave assisted extraction, enzyme assisted extraction, extraction using deep eutectic solvents etc. are being explored currently for production of phlorotannin-rich extracts. In spite of such well documented bioactivities, very few phlorotannin-based nutraceuticals are available commercially which highlights the significance of generating consumer awareness about their physiological benefits. However, for industry level commercialization accurate quantification of phlorotannins with respect to the different classes is vital requiring sophisticated analytical techniques such as mass spectrometry, 1 H-NMR spectroscopy etc. owing to the wide structural diversity. This review summarizes the extraction and bioactivities of phlorotannins based on the findings of in vivo and in vitro studies.
ISSN:0921-8971
1573-5176
DOI:10.1007/s10811-022-02749-4