Synthesis of enol phosphates directly from ketones via a modified one-pot Perkow reaction

A modified Perkow reaction, named Perkow-Shi reaction, was developed based on the one-pot α-tosyloxylation of ketones following by addition of P(iii)-reagents and 4 Å molecular sieves. Diversity of enol phosphates, as well as enol phosphonates, enol phosphinates, and enol phosphoramidates were synth...

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Bibliographic Details
Published in:RSC advances 2022-05, Vol.12 (23), p.14844-14848
Main Authors: Guo, Huichuang, Zhang, Yulong, Li, Zhenya, Zhao, Peichao, Li, Ning, Shi, Enxue
Format: Article
Language:English
Subjects:
Chemistry
Ketones
Molecular sieves
Phosphates
Phosphonates
Reagents
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Summary:A modified Perkow reaction, named Perkow-Shi reaction, was developed based on the one-pot α-tosyloxylation of ketones following by addition of P(iii)-reagents and 4 Å molecular sieves. Diversity of enol phosphates, as well as enol phosphonates, enol phosphinates, and enol phosphoramidates were synthesized in high yields directly from the ubiquitously available ketones instead of the unfavourable α-chloroketones under a mild and environmental friendly condition.
ISSN:2046-2069
2046-2069
DOI:10.1039/d2ra02340g