Circulating microRNAs in patients with aneurysmal dilatation of coronary arteries

To understand the mechanism underlying coronary artery abnormal dilatation (CAAD), the present study identified and compared the expression of circulating microRNAs (miRNAs) in three groups of patients. Group 1 included 20 patients with CAAD, Group 2 included 20 patients with angiographically confir...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2022-06, Vol.23 (6), Article 404
Main Authors: Iwanczyk, Sylwia, Lehmann, Tomasz, Cieslewicz, Artur, Radziemski, Artur, Malesza, Katarzyna, Wrotynski, Michal, Jagodzinski, Pawel P, Grygier, Marek, Lesiak, Maciej, Araszkiewicz, Aleksander
Format: Article
Language:English
Subjects:
Aneurysms
Angina pectoris
Atherosclerosis
Cardiovascular disease
Care and treatment
Coronary heart disease
Coronary vessels
Development and progression
Gene expression
Genetic aspects
Health aspects
Ischemia
Kinases
Medical imaging
MicroRNA
MicroRNAs
Physiology
Plasma
Values
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Summary:To understand the mechanism underlying coronary artery abnormal dilatation (CAAD), the present study identified and compared the expression of circulating microRNAs (miRNAs) in three groups of patients. Group 1 included 20 patients with CAAD, Group 2 included 20 patients with angiographically confirmed coronary artery disease (CAD), and Group 3 included 20 patients with normal coronary arteries (control). miRNAs were isolated from plasma samples and were profiled using PCR arrays and miRCURY LNA Serum/Plasma Focus PCR Panels. The present study demonstrated that the plasma miRNA levels were significantly different in Group 1 compared with in Group 2 and Group 3 (fold change >2 and P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2022.11331