Ultra-fast dynamic line-field optical coherence elastography

In this work, we present an ultra-fast line-field optical coherence elastography system (LF-OCE) with an 11.5 MHz equivalent A-line rate. The system was composed of a line-field spectral domain optical coherence tomography system based on a supercontinuum light source, Michelson-type interferometer,...

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Bibliographic Details
Published in:Optics letters 2021-10, Vol.46 (19), p.4742-4744
Main Authors: Singh, Manmohan, Schill, Alexander W, Nair, Achuth, Aglyamov, Salavat R, Larina, Irina V, Larin, Kirill V
Format: Article
Language:English
Subjects:
Animals
Coherence
Cornea
Elastic waves
Elasticity
Elasticity Imaging Techniques
In vivo methods and tests
Light sources
Line spectra
Mechanical tests
Phantoms, Imaging
Rabbits
Tomography, Optical Coherence
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Summary:In this work, we present an ultra-fast line-field optical coherence elastography system (LF-OCE) with an 11.5 MHz equivalent A-line rate. The system was composed of a line-field spectral domain optical coherence tomography system based on a supercontinuum light source, Michelson-type interferometer, and a high-speed 2D spectrometer. The system performed ultra-fast imaging of elastic waves in tissue-mimicking phantoms of various elasticities. The results corroborated well with mechanical testing. Following validation, LF-OCE measurements were made in in situ and in in vivo rabbit corneas under various conditions. The results show the capability of the system to rapidly image elastic waves in tissues.
ISSN:0146-9592
1539-4794
1539-4794
DOI:10.1364/OL.435278