Prognostic Value of Nutritional Indexes in Evaluating the 1-Year Results after Implantation of the Carillon Mitral Contour System

Background: The prognostic importance of nutritional indexes has been shown in some diseases. We aimed to examine the prognostic value of these indexes in patients implanted with the Carillon Mitral Contour System(CMCS). Methods: Fifty-four patients who underwent successful CMCS implantation were ev...

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Bibliographic Details
Published in:Acta Cardiologica Sinica 2022-05, Vol.38 (3), p.362-372
Main Authors: Tolunay, Hatice, Yasar, Salim, Asil, Serkan, Yildirim, Erkan, Yasar, Ayse Saatci, Celik, Murat, Yuksel, Uygar Cagdas, Barcin, Cem
Format: Article
Language:English
Subjects:
Carillon Mitral Contour System
Controlling nutritional status
Geriatric nutritional risk index
Heart failure
MEDLINE
Original
Prognostic nutritional index
SCIE
Scopus
Severe mitral regurgitation
Valvular and Structural Heart Disease
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Summary:Background: The prognostic importance of nutritional indexes has been shown in some diseases. We aimed to examine the prognostic value of these indexes in patients implanted with the Carillon Mitral Contour System(CMCS). Methods: Fifty-four patients who underwent successful CMCS implantation were evaluated. Prognostic nutritional index (PNI), geriatric nutritional risk index (GNRI) and controlling nutritional status (CONUT) scores were calculated. The relationships between these indexes and 1-year clinical outcomes including all-cause mortality and re-hospitalization due to heart failure were investigated. Results: In Kaplan-Meier analysis, 1-year all-cause mortality rates were significantly higher in the patients with low PNI and GNRI and high CONUT scores (52.0% vs. 0%, p ＜ 0.001; 54.2% vs. 0%, p ＜ 0.001; 52.4%, 6.1%, p ＜ 0.001; respectively). For the composite endpoint, a significant difference was observed between those below and above the cut-off values (70.0% vs. 16.7%, p ＜ 0.001; 75.0% vs. 23.3%, p ＜ 0.001; 66.7% vs. 20.8%, p ＜ 0.001, respectively). In multivariate Cox regression analysis, GNRI was determined to be an independent predictor of 1-year all-cause mortality [hazard ratio: 0.707; 95% confidence interval: 0.510-0.979; p = 0.037]. Conclusions: Nutritional indexes have prognostic value in predicting 1-year all-cause mortality in severe functional mitral regurgitation patients undergoing CMCS implantation. In particular, GNRI can guide the selection of patients who will benefit from CMCS.
ISSN:1011-6842
DOI:10.6515/ACS.202205_38(3).20211222A