Anti-Inflammatory and Antioxidant Effects of the Indole-Derived N-Salicyloyltryptamine on Peritonitis and Joint Disability Induced by Carrageenan in Rodents

Purpose. To investigate the anti-inflammatory and antioxidant activities of N-salicyloyltryptamine (NST) in experimental models of carrageenan (Cg)-induced peritonitis in mice, and evaluation of the effects of NST on Cg-induced joint disability in rats. Methods. Female Swiss mice were submitted to C...

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Published in:Evidence-based complementary and alternative medicine 2022, Vol.2022, p.5524107-8
Main Authors: Sousa-Neto, B. P., Cunha, F. V. M., Nunes, Daniel Barbosa, Gomes, B. S., Amorim, Layane Valeria, Lopes, Everton Moraes, Gutierrez, S. J. C., Almeida, F. R. C., Arcanjo, D. D. R., Souza, M. F. V., Oliveira, F. A.
Format: Article
Language:English
Subjects:
Acids
Animals
Anti-inflammatory agents
Antioxidants
Carrageenans
Catalase
Inflammation
Leukocyte migration
Leukocytes (neutrophilic)
Nitrogen dioxide
Peritonitis
Peroxidase
Potassium
Proteins
Reactive oxygen species
Reagents
Rheumatoid arthritis
Sodium
Thiobarbituric acid
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Summary:Purpose. To investigate the anti-inflammatory and antioxidant activities of N-salicyloyltryptamine (NST) in experimental models of carrageenan (Cg)-induced peritonitis in mice, and evaluation of the effects of NST on Cg-induced joint disability in rats. Methods. Female Swiss mice were submitted to Cg-induced peritonitis in mice or Cg-induced joint disability in rats after intraperitoneal injection of NST (100 or 200 mg/kg). Total leukocyte count, total protein concentration, myeloperoxidase (MPO) and catalase (CAT) activities, and nitrite (NO2−) and thiobarbituric acid reactive species (TBARS) levels were determined. Results. NST significantly decrease the migration of leukocytes to peritoneal exudate. Cg induces inflammatory responses mediated by expression of reactive oxygen species (ROS). The results further showed that NST significantly decreased MPO and CAT activities, as well as reduced NO2− and TBARS levels, compared with the vehicle group. Animals treated with NST significantly reduced paw elevation time (PET) on the first hour after induction of joint injury, and this effect was sustained throughout the analysis. Conclusion. NST presented anti-inflammatory and antioxidant effects in experimental models of carrageenan-induced peritonitis and joint disability in mice and rats, respectively, which may be related to the modulation of neutrophils migration as well as the involvement of antioxidant mechanisms.
ISSN:1741-427X
1741-4288
DOI:10.1155/2022/5524107