Concomitant dysregulation of androgen secretion and dysfunction of adipose tissue induced insulin resistance

Hyperandrogenism and hyperinsulinemia have resulted from dysfunction of the theca cell of the ovary and adipose tissue and each one potentiates the other in patients with androgen excess disorders polycystic ovary disease and idiopathic hirsutism. Possible external and/or internal triggers can produ...

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Bibliographic Details
Published in:World journal of diabetes 2022-05, Vol.13 (5), p.417-419
Main Author: Al-Nimer, Marwan Sm
Format: Article
Language:English
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Letter to the Editor
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Summary:Hyperandrogenism and hyperinsulinemia have resulted from dysfunction of the theca cell of the ovary and adipose tissue and each one potentiates the other in patients with androgen excess disorders polycystic ovary disease and idiopathic hirsutism. Possible external and/or internal triggers can produce such cellular dysfunction. There is evidence that sodium valproate acts as a trigger of cellular dysfunction and produces both hyperinsulinemia and hyperandrogenism. Therefore, the elimination of these triggers can help the patients to recover from hyperinsulinemia, insulin resistance and hyperandrogenism.
ISSN:1948-9358
1948-9358
DOI:10.4239/wjd.v13.i5.417