Mammary analogue secretory carcinoma presenting with cervical lymphadenopathy: A rare case report with review of the literature

• Published in: International journal of surgery case reports 2022-06, Vol.95, p.107132-107132, Article 107132
• Main Authors: Omar, Sami S., Daugherty, Emily C., Rasul, Kakil I., Salih, Fahmi M., Hamza, Hawro T., Kakamad, Fahmi H., Salih, Abdulwahid M.
• Format: Article
• Language: English
• Subjects: Case Report; Mammary analogue secretory carcinoma; NTRK fusion gene; Parotid gland tumor; Salivary gland
• ISSN: 2210-2612; 2210-2612
• DOI: 10.1016/j.ijscr.2022.107132

Mammary analogue secretory carcinoma is a rare malignant tumor of the salivary glands that typically involves the major glands. The aim of the current study is to report a rare case of mammary analogue secretory carcinoma that presented with left cervical lymphadenopathy. A 59-year-old lady presented with left cervical lymphadenopathy. Tissue biopsy and immunohistochemistry revealed metastatic carcinoma, favoring ovarian origin. Staging workup was performed and, ultimately, the patient was treated as having a carcinoma of unknown primary. After showing partial response to therapy, left side neck dissection was performed. Based on better assessment of the histologic picture and a broader panel of immunohistochemistry performed on the excision specimen, the final diagnosis was that of mammary analogue secretory carcinoma. Mammary analogue secretory carcinoma is usually an indolent salivary gland carcinoma, with the majority of patients presenting with a slow-growing, painless mass measuring approximately 2 cm in size, and a reported duration ranging from 2 months to several years. In certain cases, pain and facial paralysis have been reported. It could also be found incidentally during radiologic assessment for thyroid illness or routine dental screening. Diagnosing mammary analogue secretory carcinoma is challenging, and this should be in the differential diagnosis list of metastatic carcinomas to cervical lymph nodes. •Mammary analogue secretory carcinoma (MASC) is a rare malignant salivary gland neoplasm.•MASC has similar histologic and molecular characteristics to breast secretory carcinoma.•MASC was first reported in 2010 by Skalova et al.•In this report, a brief review regarding this condition is discussed.