Non-Melanoma Skin Cancer: A Genetic Update and Future Perspectives

Skin cancer is one of the main types of cancer worldwide, and non-melanoma skin cancer (NMSC) is the most frequent within this group. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common types. Multifactorial features are well-known for cancer development, and new hallmar...

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Bibliographic Details
Published in:Cancers 2022-05, Vol.14 (10), p.2371
Main Authors: Zambrano-Román, Marianela, Padilla-Gutiérrez, Jorge R, Valle, Yeminia, Muñoz-Valle, José F, Valdés-Alvarado, Emmanuel
Format: Article
Language:English
Subjects:
Apoptosis
Basal cell carcinoma
Carcinogenesis
Cell cycle
Cell growth
DNA damage
DNA repair
Epigenetics
Fibroblasts
Gene expression
Genetic analysis
Health care
Immune system
Medical prognosis
Melanoma
Mutation
Public health
Radiation
Review
Skin cancer
Squamous cell carcinoma
Tumor microenvironment
Tumors
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Summary:Skin cancer is one of the main types of cancer worldwide, and non-melanoma skin cancer (NMSC) is the most frequent within this group. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common types. Multifactorial features are well-known for cancer development, and new hallmarks are gaining relevance. Genetics and epigenetic regulation play an essential role in cancer susceptibility and progression, as well as the variety of cells and molecules that interact in the tumor microenvironment. In this review, we provide an update on the genetic features of NMSC, candidate genes, and new therapies, considering diverse perspectives of skin carcinogenesis. The global health situation and the pandemic have been challenging for health care systems, especially in the diagnosis and treatment of patients with cancer. We provide innovative approaches to overcome the difficulties in the current clinical dynamics.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14102371