Cardiovascular Biomarkers: Lessons of the Past and Prospects for the Future

Cardiovascular diseases (CVDs) are a major healthcare burden on the population worldwide. Early detection of this disease is important in prevention and treatment to minimise morbidity and mortality. Biomarkers are a critical tool to either diagnose, screen, or provide prognostic information for pat...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-05, Vol.23 (10), p.5680
Main Authors: Omran, Farah, Kyrou, Ioannis, Osman, Faizel, Lim, Ven Gee, Randeva, Harpal Singh, Chatha, Kamaljit
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Biomarkers
Cardiology
Cardiovascular diseases
Cardiovascular Diseases - diagnosis
Cardiovascular System
Coronary artery disease
Disease
Early Diagnosis
Enzymes
Health care
Heart
Heart diseases
Humans
Laboratories
Morbidity
Plasma
Pulmonary embolisms
Review
Risk assessment
Trauma
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Summary:Cardiovascular diseases (CVDs) are a major healthcare burden on the population worldwide. Early detection of this disease is important in prevention and treatment to minimise morbidity and mortality. Biomarkers are a critical tool to either diagnose, screen, or provide prognostic information for pathological conditions. This review discusses the historical cardiac biomarkers used to detect these conditions, discussing their application and their limitations. Identification of new biomarkers have since replaced these and are now in use in routine clinical practice, but still do not detect all disease. Future cardiac biomarkers are showing promise in early studies, but further studies are required to show their value in improving detection of CVD above the current biomarkers. Additionally, the analytical platforms that would allow them to be adopted in healthcare are yet to be established. There is also the need to identify whether these biomarkers can be used for diagnostic, prognostic, or screening purposes, which will impact their implementation in routine clinical practice.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23105680