Influence of Advanced Organ Support (ADVOS) on Cytokine Levels in Patients with Acute-on-Chronic Liver Failure (ACLF)

Background: ADVanced Organ Support (ADVOS) is a novel type of extracorporeal albumin dialysis that supports multiorgan function in patients with acute-on-chronic liver failure (ACLF). No data exist on whether ADVOS affects inflammatory cytokine levels, which play a relevant role in ACLF. Aim: Our ai...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical medicine 2022-05, Vol.11 (10), p.2782
Main Authors: Kaps, Leonard, Schleicher, Eva Maria, Medina Montano, Carolina, Bros, Matthias, Gairing, Simon Johannes, Ahlbrand, Constantin Johannes, Michel, Maurice, Klimpke, Pascal, Kremer, Wolfgang Maximilian, Holtz, Stefan, Boedecker-Lips, Simone Cosima, Galle, Peter Robert, Kraus, Daniel, Schattenberg, Jörn M, Labenz, Christian, Weinmann-Menke, Julia
Format: Article
Language:English
Subjects:
Blood
Clinical medicine
Cytokines
Dialysate
Electrolytes
Hemodialysis
Inflammation
Laboratories
Liver cirrhosis
Metabolites
Physiology
Proteins
Renal replacement therapy
Software
Toxins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: ADVanced Organ Support (ADVOS) is a novel type of extracorporeal albumin dialysis that supports multiorgan function in patients with acute-on-chronic liver failure (ACLF). No data exist on whether ADVOS affects inflammatory cytokine levels, which play a relevant role in ACLF. Aim: Our aim was to quantify cytokine levels both before and after a single ADVOS treatment in patients with ACLF at a regular dialysis ward. Methods and results: In this prospective study, 15 patients (60% men) with ACLF and an indication for renal replacement therapy were included. Patient liver function was severely compromised, reflected by a median CLIF-consortium ACLF score of 38 (IQR 35; 40). Blood samples were directly taken before and after ADVOS dialysis. The concentration of cytokines for IL-1β, IFN-α2, IFN-γ, TNF-α, MCP-1, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-18, IL-23, IL-33 were quantified via a cytometric bead array. We found no significant (p > 0.05) change in cytokine levels, even when patients were stratified for dialysis time (
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11102782