Prevalence and Factors of Osteoporosis and High Risk of Osteoporotic Fracture in Patients with Ankylosing Spondylitis: A Multicenter Comparative Study of Bone Mineral Density and the Fracture Risk Assessment Tool

We investigated the prevalence of and the factors associated with a high risk of osteoporotic fractures in Korean patients with ankylosing spondylitis (AS). This was a multicenter, retrospective study including 219 AS patients from five university hospitals; the control group was selected by matchin...

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Bibliographic Details
Published in:Journal of clinical medicine 2022-05, Vol.11 (10), p.2830
Main Authors: Kim, Ji-Won, Park, Sunghoon, Jung, Ju-Yang, Kim, Hyoun-Ah, Kwon, Seong-Ryul, Choi, Sang Tae, Kim, Sung-Soo, Kim, Sang-Hyeon, Suh, Chang-Hee
Format: Article
Language:English
Subjects:
Age
Arthritis
Bone density
Clinical medicine
Disease
Fractures
Hospitals
Medical records
Mortality
Older people
Osteoporosis
Patients
Population
Risk assessment
Software
Tumor necrosis factor-TNF
Vertebrae
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Summary:We investigated the prevalence of and the factors associated with a high risk of osteoporotic fractures in Korean patients with ankylosing spondylitis (AS). This was a multicenter, retrospective study including 219 AS patients from five university hospitals; the control group was selected by matching age and sex with those of the AS patients. The fracture risk was evaluated based on bone mineral density (BMD) measured by dual-energy X-ray absorptiometry and the fracture risk assessment tool (FRAX) with/without BMD. The mean age of the patients was 47.6 years, and 144 (65.8%) patients were men. According to the WHO criteria and FRAX with/without BMD, the candidates for pharmacological treatment were 44 (20.1%), 20 (13.2%), and 23 (15.1%) patients, respectively, significantly more than those in the healthy control group. Among them, the proportion of patients receiving osteoporosis treatment was 39.1-75%. In logistic regression analysis, menopause was an independent factor for the high risk of fracture according to the WHO criteria and FRAX with/without BMD. C-reactive protein level (odds ratio (OR) 3.8 and OR 6) and glucocorticoid use (OR 1.5 and OR 1.7) were associated with a high risk of osteoporotic fracture based on FRAX without BMD and osteoporosis diagnosed according to the WHO criteria. Our study suggests that both FRAX and WHO criteria may be complementary for treatment decisions to reduce osteoporotic fractures in patients with AS.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11102830