The Cytoskeletal Protein Zyxin Inhibits Retinoic Acid Signaling by Destabilizing the Maternal mRNA of the RXRγ Nuclear Receptor

Zyxin is an LIM-domain-containing protein that regulates the assembly of F-actin filaments in cell contacts. Additionally, as a result of mechanical stress, Zyxin can enter nuclei and regulate gene expression. Previously, we found that Zyxin could affect mRNA stability of the maternally derived stem...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2022-05, Vol.23 (10), p.5627
Main Authors: Parshina, Elena A, Orlov, Eugeny E, Zaraisky, Andrey G, Martynova, Natalia Y
Format: Article
Language:English
Subjects:
Acids
Actin
Contact stresses
Cytoskeletal Proteins - genetics
Cytoskeletal Proteins - metabolism
Cytoskeleton
Destabilization
Efficiency
Embryogenesis
Embryos
Filaments
Gene expression
Kinases
mRNA stability
Proteins
Retinoic acid
Retinoid X Receptor gamma
RNA, Messenger, Stored
Signal Transduction
Stability
Tretinoin - pharmacology
Zyxin - genetics
Zyxin - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Zyxin is an LIM-domain-containing protein that regulates the assembly of F-actin filaments in cell contacts. Additionally, as a result of mechanical stress, Zyxin can enter nuclei and regulate gene expression. Previously, we found that Zyxin could affect mRNA stability of the maternally derived stemness factors of Pou5f3 family in Xenopus laevis embryos through binding to Y-box factor1. In the present work, we demonstrate that Zyxin can also affect mRNA stability of the maternally derived retinoid receptor Rxrγ through the same mechanism. Moreover, we confirmed the functional link between Zyxin and Rxrγ-dependent gene expression. As a result, Zyxin appears to play an essential role in the regulation of the retinoic acid signal pathway during early embryonic development. Besides, our research indicates that the mechanism based on the mRNA destabilization by Zyxin may take part in the control of the expression of a fairly wide range of maternal genes.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23105627