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Viral aetiology and clinico-epidemiological features of acute encephalitis syndrome in eastern India
This study reports clinico-epidemiological features and viral agents causing acute encephalitis syndrome (AES) in the eastern Indian region through hospital-based case enrolment during April 2011 to July 2012. Blood and CSF samples of 526 AES cases were investigated by serology and/or PCR. Viral aet...
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Published in: | Epidemiology and infection 2014-12, Vol.142 (12), p.2514-2521 |
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description | This study reports clinico-epidemiological features and viral agents causing acute encephalitis syndrome (AES) in the eastern Indian region through hospital-based case enrolment during April 2011 to July 2012. Blood and CSF samples of 526 AES cases were investigated by serology and/or PCR. Viral aetiology was identified in 91 (17·2%) cases. Herpes simplex virus (HSV; types I or II) was most common (16·1%), followed by measles (2·6%), Japanese encephalitis virus (1·5%), dengue virus (0·57%), varicella zoster virus (0·38%) and enteroviruses (0·19%). Rash, paresis and cranial nerve palsies were significantly higher (P |
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K. ; DWIBEDI, B. ; KAR, S. K. ; DIXIT, S. ; SABAT, J. ; PANDA, M.</creator><creatorcontrib>RATHORE, S. K. ; DWIBEDI, B. ; KAR, S. K. ; DIXIT, S. ; SABAT, J. ; PANDA, M.</creatorcontrib><description>This study reports clinico-epidemiological features and viral agents causing acute encephalitis syndrome (AES) in the eastern Indian region through hospital-based case enrolment during April 2011 to July 2012. Blood and CSF samples of 526 AES cases were investigated by serology and/or PCR. Viral aetiology was identified in 91 (17·2%) cases. Herpes simplex virus (HSV; types I or II) was most common (16·1%), followed by measles (2·6%), Japanese encephalitis virus (1·5%), dengue virus (0·57%), varicella zoster virus (0·38%) and enteroviruses (0·19%). Rash, paresis and cranial nerve palsies were significantly higher (P < 0·05) with viral AES. Case-fatality rates were 10·9% and 6·2% in AES cases with and without viral aetiology, respectively. Simultaneous infection of HSV I and measles was observed in seven cases. This report provides the first evidence on viral aetiology of AES viruses from eastern India showing dominance of HSV that will be useful in informing the public health system.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268813003397</identifier><identifier>PMID: 24476571</identifier><identifier>CODEN: EPINEU</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adolescent ; Adult ; Antigens ; Biological and medical sciences ; Convulsions & seizures ; Dengue fever ; Dengue virus ; Encephalitis ; Encephalitis, Viral - epidemiology ; Encephalitis, Viral - virology ; Enzyme-Linked Immunosorbent Assay ; Epidemics ; Etiology ; Female ; Fundamental and applied biological sciences. Psychology ; Health outcomes ; Herpes simplex virus ; Hospitals ; Humans ; India - epidemiology ; Infections ; Infectious diseases ; Japanese encephalitis virus ; Japanese encephalitis viruses ; Laboratories ; Male ; Measles ; Microbiology ; Mortality ; Original Papers ; Pathogens ; Patients ; Polymerase Chain Reaction ; Public health ; Serotyping ; Simplexvirus ; Varicella zoster encephalitis ; Varicella-zoster virus ; Viral infections ; Viruses ; West Nile virus</subject><ispartof>Epidemiology and infection, 2014-12, Vol.142 (12), p.2514-2521</ispartof><rights>Copyright © Cambridge University Press 2014</rights><rights>Cambridge University Press 2014</rights><rights>2015 INIST-CNRS</rights><rights>Cambridge University Press 2014 2014 Cambridge University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-582ca65ebb36ed224b210e4dabb0afbcf7d3471f645088e71c489287e9b3e7303</citedby><cites>FETCH-LOGICAL-c556t-582ca65ebb36ed224b210e4dabb0afbcf7d3471f645088e71c489287e9b3e7303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24477232$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0950268813003397/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793,58238,58471,72960</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28943543$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24476571$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RATHORE, S. K.</creatorcontrib><creatorcontrib>DWIBEDI, B.</creatorcontrib><creatorcontrib>KAR, S. K.</creatorcontrib><creatorcontrib>DIXIT, S.</creatorcontrib><creatorcontrib>SABAT, J.</creatorcontrib><creatorcontrib>PANDA, M.</creatorcontrib><title>Viral aetiology and clinico-epidemiological features of acute encephalitis syndrome in eastern India</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>This study reports clinico-epidemiological features and viral agents causing acute encephalitis syndrome (AES) in the eastern Indian region through hospital-based case enrolment during April 2011 to July 2012. Blood and CSF samples of 526 AES cases were investigated by serology and/or PCR. Viral aetiology was identified in 91 (17·2%) cases. Herpes simplex virus (HSV; types I or II) was most common (16·1%), followed by measles (2·6%), Japanese encephalitis virus (1·5%), dengue virus (0·57%), varicella zoster virus (0·38%) and enteroviruses (0·19%). Rash, paresis and cranial nerve palsies were significantly higher (P < 0·05) with viral AES. Case-fatality rates were 10·9% and 6·2% in AES cases with and without viral aetiology, respectively. Simultaneous infection of HSV I and measles was observed in seven cases. This report provides the first evidence on viral aetiology of AES viruses from eastern India showing dominance of HSV that will be useful in informing the public health system.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Convulsions & seizures</subject><subject>Dengue fever</subject><subject>Dengue virus</subject><subject>Encephalitis</subject><subject>Encephalitis, Viral - epidemiology</subject><subject>Encephalitis, Viral - virology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Epidemics</subject><subject>Etiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health outcomes</subject><subject>Herpes simplex virus</subject><subject>Hospitals</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Japanese encephalitis virus</subject><subject>Japanese encephalitis viruses</subject><subject>Laboratories</subject><subject>Male</subject><subject>Measles</subject><subject>Microbiology</subject><subject>Mortality</subject><subject>Original Papers</subject><subject>Pathogens</subject><subject>Patients</subject><subject>Polymerase Chain Reaction</subject><subject>Public health</subject><subject>Serotyping</subject><subject>Simplexvirus</subject><subject>Varicella zoster encephalitis</subject><subject>Varicella-zoster virus</subject><subject>Viral infections</subject><subject>Viruses</subject><subject>West Nile virus</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkUuLFDEUhYMozjj6A1woARHclN68qzaCDD4GBlz42Bap5FZPmqqkTaqE_vdW2e04o4irLM53D-fkEPKYwUsGzLz6BI0CruuaCQAhGnOHnDKpm0pKaO6S01WuVv2EPChlCwANr819csKlNFoZdkr815DtQC1OIQ1ps6c2euqGEINLFe6Cx_GnENxC9WinOWOhqafWzRNSjA53V3YIUyi07KPPaUQaIkVbJsyRXkQf7ENyr7dDwUfH94x8eff28_mH6vLj-4vzN5eVU0pPlaq5s1ph1wmNnnPZcQYove06sH3neuOFNKzXUkFdo2FO1mshbDqBRoA4I68Pvru5G9E7jNNSrt3lMNq8b5MN7W0lhqt2k763DVOM1_Vi8OJokNO3GcvUjqE4HAYbMc2lZQYUaCkb_n9Ucw7KAFtjPfsD3aY5x-UnVgqEloLphWIHyuVUSsb-OjeDdp27_Wvu5ebpzcLXF7_2XYDnR8CWZcE-2-hC-c3VjRRKioV7cuC2ZUr5lo_hYm0rjuHs2OXgN3ijwz_j_QCKEswY</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>RATHORE, S. 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K.</au><au>DWIBEDI, B.</au><au>KAR, S. K.</au><au>DIXIT, S.</au><au>SABAT, J.</au><au>PANDA, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Viral aetiology and clinico-epidemiological features of acute encephalitis syndrome in eastern India</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>142</volume><issue>12</issue><spage>2514</spage><epage>2521</epage><pages>2514-2521</pages><issn>0950-2688</issn><eissn>1469-4409</eissn><coden>EPINEU</coden><abstract>This study reports clinico-epidemiological features and viral agents causing acute encephalitis syndrome (AES) in the eastern Indian region through hospital-based case enrolment during April 2011 to July 2012. Blood and CSF samples of 526 AES cases were investigated by serology and/or PCR. Viral aetiology was identified in 91 (17·2%) cases. Herpes simplex virus (HSV; types I or II) was most common (16·1%), followed by measles (2·6%), Japanese encephalitis virus (1·5%), dengue virus (0·57%), varicella zoster virus (0·38%) and enteroviruses (0·19%). Rash, paresis and cranial nerve palsies were significantly higher (P < 0·05) with viral AES. Case-fatality rates were 10·9% and 6·2% in AES cases with and without viral aetiology, respectively. Simultaneous infection of HSV I and measles was observed in seven cases. This report provides the first evidence on viral aetiology of AES viruses from eastern India showing dominance of HSV that will be useful in informing the public health system.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>24476571</pmid><doi>10.1017/S0950268813003397</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Antigens Biological and medical sciences Convulsions & seizures Dengue fever Dengue virus Encephalitis Encephalitis, Viral - epidemiology Encephalitis, Viral - virology Enzyme-Linked Immunosorbent Assay Epidemics Etiology Female Fundamental and applied biological sciences. Psychology Health outcomes Herpes simplex virus Hospitals Humans India - epidemiology Infections Infectious diseases Japanese encephalitis virus Japanese encephalitis viruses Laboratories Male Measles Microbiology Mortality Original Papers Pathogens Patients Polymerase Chain Reaction Public health Serotyping Simplexvirus Varicella zoster encephalitis Varicella-zoster virus Viral infections Viruses West Nile virus |
title | Viral aetiology and clinico-epidemiological features of acute encephalitis syndrome in eastern India |
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