The spread of drug-resistant tuberculosis in children: an Italian case series

Drug-resistant paediatric tuberculosis (TB) is an overlooked global problem. In Italy, the epidemiology of TB has recently changed and data regarding drug-resistant forms in the paediatric setting is scanty. The aim of this case series was to report the cases of drug-resistant TB, diagnosed between...

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Bibliographic Details
Published in:Epidemiology and infection 2014-10, Vol.142 (10), p.2049-2056
Main Authors: MIGNONE, F., CODECASA, L. R., SCOLFARO, C., RAFFALDI, I., LANCELLA, L., FERRARESE, M., GARAZZINO, S., MARABOTTO, C., ESPOSITO, S., GABIANO, C., LIPRERI, R., TOVO, P.-A.
Format: Article
Language:English
Subjects:
Adolescent
Antitubercular Agents - therapeutic use
Antituberculars
Biological and medical sciences
Child
Child health services
Child, Preschool
Cohort Studies
Cough
Disease resistance
Drug resistance
Emigration and Immigration - statistics & numerical data
Epidemiology
Female
Fever
Fundamental and applied biological sciences. Psychology
Humans
Infant
Infectious diseases
Italy - epidemiology
Male
Microbiology
Multidrug resistant tuberculosis
Mycobacteria
Mycobacterium
Original Papers
Pediatrics
Pulmonary tuberculosis
Retrospective Studies
Tertiary Care Centers
Tuberculosis
Tuberculosis - drug therapy
Tuberculosis - epidemiology
Tuberculosis - transmission
Tuberculosis, Multidrug-Resistant - drug therapy
Tuberculosis, Multidrug-Resistant - epidemiology
Tuberculosis, Multidrug-Resistant - transmission
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - epidemiology
Tuberculosis, Pulmonary - transmission
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Summary:Drug-resistant paediatric tuberculosis (TB) is an overlooked global problem. In Italy, the epidemiology of TB has recently changed and data regarding drug-resistant forms in the paediatric setting is scanty. The aim of this case series was to report the cases of drug-resistant TB, diagnosed between June 2006 and July 2010 in four Italian tertiary centres for paediatric infectious diseases, in children and adolescents living in Italy. Twenty-two children were enrolled, of these 17 were resistant to one or more drugs and five had multidrug-resistant TB. All but one child were either foreign born or had at least one foreign parent. Twenty-one patients completed their treatment without clinical or radiological signs of activity at the end of treatment, and one patient was lost to follow up. The outcomes were good, with few adverse effects using second-line anti-TB drugs. Although this series is limited, it might already reflect the worrisome increase of drug-resistant TB, even in childhood.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268813003191