Epidemiological analysis of critically ill adult patients with pandemic influenza A(H1N1) in South Korea

A total of 245 patients with confirmed 2009 H1N1 influenza were admitted to the intensive-care units of 28 hospitals (South Korea). Their mean age was 55·3 years with 68·6% aged >50 years, and 54·7% male. Nine were obese and three were pregnant. One or more comorbidities were present in 83·7%, an...

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Bibliographic Details
Published in:Epidemiology and infection 2013-05, Vol.141 (5), p.1070-1079
Main Authors: HONG, S. B., CHOI, E. Y., KIM, S. H., SUH, G. Y., PARK, M. S., LEE, M. G., LIM, J., LEE, H. K., KIM, S. C., KIM, S. J., KIM, K. U., KWAK, S. H., KOH, Y.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antiviral Agents - therapeutic use
Bacterial infections
Biological and medical sciences
Body mass index
Corticosteroids
Critical care
Critical Illness
Female
Fundamental and applied biological sciences. Psychology
H1N1 subtype influenza A virus
Hospital admissions
Hospitals
Humans
Illnesses
Infections
Influenza
Influenza A Virus, H1N1 Subtype
Influenza, Human - drug therapy
Influenza, Human - epidemiology
Influenza, Human - virology
Intensive care units
Leukocytes
Lung diseases
Male
Medical records
Microbiology
Middle Aged
Miscellaneous
Mortality
Original Papers
Pandemics
Pneumonia
Republic of Korea - epidemiology
Risk Factors
Swine flu
Symptomatology
Ventilators
Virology
Young Adult
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Summary:A total of 245 patients with confirmed 2009 H1N1 influenza were admitted to the intensive-care units of 28 hospitals (South Korea). Their mean age was 55·3 years with 68·6% aged >50 years, and 54·7% male. Nine were obese and three were pregnant. One or more comorbidities were present in 83·7%, and nosocomial acquisition occurred in 14·3%. In total, 107 (43·7%) patients received corticosteroids and 66·1% required mechanical ventilation. Eighty (32·7%) patients died within 30 days after onset of symptoms and 99 (40·4%) within 90 days. Multivariate logistic regression analysis showed that the clinician's decision to prescribe corticosteroids, older age, Sequential Organ Failure Assessment score and nosocomial bacterial pneumonia were independent risk factors for 90-day mortality. In contrast with Western countries, critical illness in Korea in relation to 2009 H1N1 was most common in older patients with chronic comorbidities; nosocomial acquisition occurred occasionally but disease in obese or pregnant patients was uncommon.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268812001604