Human metapneumovirus infection among family members

The transmission of human metapneumovirus (hMPV) among family members is not well understood. We identified 15 families in which multiple members were diagnosed with hMPV infection by real-time PCR in 2008 and 2010. Index patients ranged in age from 2 years to 11 years (median 5 years), and all 15 i...

Full description

Saved in:
Bibliographic Details
Published in:Epidemiology and infection 2013-04, Vol.141 (4), p.827-832
Main Authors: MATSUZAKI, Y., ITAGAKI, T., IKEDA, T., AOKI, Y., ABIKO, C., MIZUTA, K.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Biological and medical sciences
Bronchitis
Child
Child, Preschool
Disease Outbreaks - prevention & control
Elementary schools
Family
Female
Fever
Fundamental and applied biological sciences. Psychology
Human metapneumovirus
Humans
Infant
Infants
Infections
Infectious diseases
Kindergarten
Kindergarten education
Male
Metapneumovirus
Metapneumovirus - isolation & purification
Microbiology
Middle Aged
Miscellaneous
Original Papers
Other Respiratory infections
Paramyxoviridae Infections - epidemiology
Paramyxoviridae Infections - transmission
Patients
Phylogenetics
Real-Time Polymerase Chain Reaction
Symptomatology
Virology
Viruses
Womens studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The transmission of human metapneumovirus (hMPV) among family members is not well understood. We identified 15 families in which multiple members were diagnosed with hMPV infection by real-time PCR in 2008 and 2010. Index patients ranged in age from 2 years to 11 years (median 5 years), and all 15 index cases were children who attended primary school, kindergarten, or nursery school. Contact patients ranged in age from 2 months to 46 years (median 6 years). Excluding five adult cases, contact patients were significantly younger than index patients (P = 0·0389). Of the 12 contact children, seven (58%) were infants who were taken care of at home. The serial interval between the onset of symptoms in an index patient and the onset of symptoms in a contact patient was estimated to be 5 days. These results suggest that the control of school-based outbreaks is important for preventing hMPV infection in infants.
ISSN:0950-2688
1469-4409
DOI:10.1017/S095026881200129X