Adiponectin, Leptin, and Resistin and the Risk of Dementia

Abstract Background Adipokines are hormones secreted by adipose tissue with roles in energy homeostasis and regulation of metabolism. Their dysregulation is suggested to contribute to the increased risk of dementia seen with midlife obesity, but longitudinal studies investigating this are scarce. We...

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Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2022-06, Vol.77 (6), p.1245-1249
Main Authors: Mooldijk, Sanne S, Ikram, Mohammad Kamran, Ikram, Mohammad Arfan
Format: Article
Language:English
Subjects:
Adipokines
Adiponectin
Adipose tissue
Alzheimer's disease
Apolipoprotein E
Body mass index
Caregivers
Cohort Studies
Dementia
Dementia - epidemiology
Dementia - etiology
Dementia disorders
Energy balance
Homeostasis
Humans
Leptin
Leptin - metabolism
Plasma levels
Population studies
Prospective Studies
Resistin
Risk assessment
Risk factors
THE JOURNAL OF GERONTOLOGY: Medical Sciences
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Summary:Abstract Background Adipokines are hormones secreted by adipose tissue with roles in energy homeostasis and regulation of metabolism. Their dysregulation is suggested to contribute to the increased risk of dementia seen with midlife obesity, but longitudinal studies investigating this are scarce. We determined the association between plasma levels of adiponectin, leptin, and resistin with the risk of dementia. Methods We performed a case–cohort study embedded in the prospective, population-based Rotterdam Study. Plasma levels of the adiponectin, leptin, and resistin were measured at baseline (1997–1999) in a random subcohort of 945 participants without dementia, and additionally in 177 participants, who were diagnosed with dementia during follow-up (until January 1, 2018). Results Higher levels of leptin and resistin were associated with a decreased risk of dementia (adjusted hazard ratio [95% confidence interval] per SD increase of log-transformed values: 0.85 [0.72–1.00] for leptin; 0.82 [0.71–0.95] for resistin). The association of leptin with dementia was further modified by body mass index and by APOE ε4 carrier status. Adiponectin levels were not associated with the risk of dementia. Conclusions These findings support the hypothesis that adipokines have a role in the pathophysiology of dementia. Future studies are warranted to confirm the findings and to explore the underlying mechanisms.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/glab267