Does Lymph Node Dissection Impact Adjuvant Treatment or Survival Outcomes in High-Risk Endometrial Cancers?

Objectives Lymphadenectomy does not improve overall survival outcomes in patients with low-risk endometrial cancers. Sentinel node mapping has a high detection rate and accuracy; however, its prognostic implications have not been well explored. We evaluated the overall survival and therapies receive...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2022-05, Vol.14 (5), p.e24710-e24710
Main Authors: Hill, Breana L, Goon, Kelsey, Fresia, Joellen, Sheeder, Jeanelle, Wolsky, Rebecca J, Alldredge, Jill
Format: Article
Language:English
Subjects:
Cancer therapies
Chemotherapy
Dissection
Endometrial cancer
Ethnicity
Histology
Lymphatic system
Medical prognosis
Metastasis
Obstetrics/Gynecology
Oncology
Pathology
Patients
Radiation therapy
Surgery
Uterine cancer
Vagina
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Summary:Objectives Lymphadenectomy does not improve overall survival outcomes in patients with low-risk endometrial cancers. Sentinel node mapping has a high detection rate and accuracy; however, its prognostic implications have not been well explored. We evaluated the overall survival and therapies received by patients undergoing varied lymph node dissection approaches for high-risk endometrial cancers. Methods Retrospective review of grade 3 endometrioid and high-grade non-endometrioid cancers at one institution over ten years. Patients who received neoadjuvant therapy and/or debulking of only grossly abnormal lymph nodes were excluded. Data was abstracted from electronic medical records. Chi-squared tests and survival analyses were used to compare groups. Results One hundred and fifty-three patients with grade 3 endometrioid, serous, clear cell, carcinosarcoma, or mixed high-grade on final pathology were identified; 16 had no lymph node dissection, 26 had sentinel lymph nodes, and 111 had complete lymph node dissection. Patients with open surgery were more likely to have complete nodes than sentinel nodes when compared to a minimally invasive approach (p
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.24710